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anti-IRF7 antibody :: Mouse anti-Human IRF7 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200077
Western Blot (WB)
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRF7, Monoclonal Antibody

 Also Known As   

IRF7 antibody

 Product Synonym Names    interferon regulatory factor 7 isoform a; interferon regulatory factor 7; irf-7; IRF7A; IRF-7H
 Product Gene Name   

anti-IRF7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    U73036 mRNA
 3D Structure    ModBase 3D Structure for Q92985
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 Clonality    Monoclonal
 Isotype    IgG1, k
 Clone Number    3D9
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human IRF-7 (1-150aa) purified from E. coli
 Clone Note    Anti-human IRF-7 mAb, clone 3D9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IRF-7 protein.
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 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-IRF7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IRF7 antibody

   Interferon regulatory factor (IRF) 7 is a member of the interferon regulatory transcription factor family. IRF7 plays an essential role in virus-activated transcription of type I interferon alpha genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
 Product Categories/Family for anti-IRF7 antibody    Hormones & Cytokines
 Applications Tested/Suitable for anti-IRF7 antibody   

ELISA (EIA), Western Blot (WB) (Cell lysate)

 Application Notes for anti-IRF7 antibody    WB: 1:1,000~ 2,000.
Recommended starting dilution is 1:1,000.
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 Western Blot (WB) of anti-IRF7 antibody    Cell lysates of Jurkat (40ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human IRF-7 (1:1,000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
anti-IRF7 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IRF7. It may not necessarily be applicable to this product.
 NCBI GI #    4758610
 NCBI GeneID    3665
 NCBI Accession #    NP_001563 [Other Products]
 NCBI GenBank Nucleotide #    NM_001572.3 [Other Products]
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 UniProt Primary Accession #    Q92985 [Other Products]
 UniProt Secondary Accession #    O00331; O00332; O00333; O75924; Q9UE79; B9EGL3 [Other Products]
 UniProt Related Accession #    Q92985 [Other Products]
 Molecular Weight    55,635 Da
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 NCBI Official Full Name    interferon regulatory factor 7 isoform a
 NCBI Official Synonym Full Names    interferon regulatory factor 7
 NCBI Official Symbol    IRF7 [Similar Products]
 NCBI Official Synonym Symbols   
IMD39; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H
[Similar Products]
 NCBI Protein Information    interferon regulatory factor 7
 UniProt Protein Name    Interferon regulatory factor 7
 Protein Family    Interferon regulatory factor
 UniProt Gene Name    IRF7 [Similar Products]
 UniProt Synonym Gene Names    IRF-7 [Similar Products]
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 NCBI Summary for IRF7    IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IRF7    Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
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Product References and Citations for anti-IRF7 antibody

   Arun P, et al., (2006) Biochem Biophys Res Commun 342 (1):50-56; Honda K, et al., (2005) Nature 434 (7034):772-777 Au W.C, et al., (2001) Virology 280 (2):273-282
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 Research Articles on IRF7    1. IRF7 plays a role in reducing bone metastasis of prostate cancer by IFN-beta-mediated NK activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRF7 antibodyPathways associated with anti-IRF7 antibody
 Reference Product  PubMed Publications
 MYD88 antibody  >114 publications with IRF7 and MYD88
 TBK1 antibody  >60 publications with IRF7 and TBK1
 ISG15 antibody  >42 publications with IRF7 and ISG15
 DDX58 antibody  >42 publications with IRF7 and DDX58
 MX1 antibody  >35 publications with IRF7 and MX1
 IFIH1 antibody  >29 publications with IRF7 and IFIH1
 IFIT1 antibody  >21 publications with IRF7 and IFIT1
 OAS1 antibody  >12 publications with IRF7 and OAS1
 RSAD2 antibody  >9 publications with IRF7 and RSAD2
 OAS2 antibody  >7 publications with IRF7 and OAS2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-IRF7 antibodyOrgans/Tissues associated with anti-IRF7 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >135 publications with IRF7 and Inflammation
 Necrosis Antibodies  >105 publications with IRF7 and Necrosis
 Liver Diseases Antibodies  >54 publications with IRF7 and Liver Diseases
 Influenza, Human Antibodies  >29 publications with IRF7 and Influenza, Human
 Kidney Diseases Antibodies  >23 publications with IRF7 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >18 publications with IRF7 and Cardiovascular Diseases
 Heart Diseases Antibodies  >10 publications with IRF7 and Heart Diseases
 Fibrosis Antibodies  >10 publications with IRF7 and Fibrosis
 Adenocarcinoma Antibodies  >9 publications with IRF7 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >8 publications with IRF7 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >234 publications with IRF7 and Blood
 Spleen Antibodies  >64 publications with IRF7 and Spleen
 Liver Antibodies  >60 publications with IRF7 and Liver
 Kidney Antibodies  >54 publications with IRF7 and Kidney
 Brain Antibodies  >49 publications with IRF7 and Brain
 Bone Antibodies  >48 publications with IRF7 and Bone
 Lung Antibodies  >47 publications with IRF7 and Lung
 Bone Marrow Antibodies  >40 publications with IRF7 and Bone Marrow
 Skin Antibodies  >30 publications with IRF7 and Skin
 Intestine Antibodies  >22 publications with IRF7 and Intestine
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