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anti-ISL1 antibody :: Mouse anti-Human ISL1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS533699
Western Blot (WB)
Unit / Price
0.1 mL  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ISL1, Monoclonal Antibody

 Also Known As   

ISL1 antibody

 Product Synonym Names    Monoclonal ISL1; Anti-ISL1; ISL-1; ISL1; ISL 1; ISL1 transcription factor; LIM
 Product Gene Name   

anti-ISL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600366
 3D Structure    ModBase 3D Structure for P61371
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1B1
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    ISL1 is a member of the LIM/homeodomain family of transcription factors. It binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. It is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Mutations in this gene have been associated with maturity-onset diabetes of the young.
 Immunogen    ISL1 antibody was raised in Mouse using a purified recombinant fragment of human ISL1 expressed in E Coli as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-ISL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ISL1 antibody

   Mouse monoclonal ISL1 antibody
 Product Categories/Family for anti-ISL1 antibody    Cell Biology
 Applications Tested/Suitable for anti-ISL1 antibody   

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-ISL1 antibody    ELISA: 1:10,000
IF: 1:200-1:1000
WB: 1:500-1:2000
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 Western Blot (WB) of anti-ISL1 antibody    Western Blot showing ISL1 antibody used against full-length ISL1 (aa1-349)-hIgGFc transfected HEK293 cell lysate (1).
anti-ISL1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ISL1. It may not necessarily be applicable to this product.
 NCBI GI #    115387114
 NCBI GeneID    3670
 NCBI Accession #    NP_002193.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002202.2 [Other Products]
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 UniProt Primary Accession #    P61371 [Other Products]
 UniProt Secondary Accession #    P20663; P47894 [Other Products]
 UniProt Related Accession #    P61371 [Other Products]
 Molecular Weight    39,036 Da
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 NCBI Official Full Name    insulin gene enhancer protein ISL-1
 NCBI Official Synonym Full Names    ISL LIM homeobox 1
 NCBI Official Symbol    ISL1 [Similar Products]
 NCBI Official Synonym Symbols   
Isl-1; ISLET1
[Similar Products]
 NCBI Protein Information    insulin gene enhancer protein ISL-1
 UniProt Protein Name    Insulin gene enhancer protein ISL-1
 Protein Family    Insulin gene enhancer protein
 UniProt Gene Name    ISL1 [Similar Products]
 UniProt Synonym Gene Names    Islet-1 [Similar Products]
 UniProt Entry Name    ISL1_HUMAN
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 NCBI Summary for ISL1    This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ISL1    ISL1: Binds to one of the cis-acting domain of the insulin gene enhancer.

Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5q11.1

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor binding; zinc ion binding; bHLH transcription factor binding; estrogen receptor binding; chromatin binding

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interleukin-12 production; positive regulation of interleukin-1 alpha production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of estrogen receptor signaling pathway; positive regulation of tyrosine phosphorylation of Stat3 protein; pancreas development; positive regulation of cell proliferation; neuron fate specification; ventricular cardiac muscle morphogenesis; negative regulation of neuron apoptosis; sensory system development; neural crest cell migration; positive regulation of DNA binding; trigeminal nerve development; pharyngeal system development; axon regeneration; spinal cord motor neuron cell fate specification; positive regulation of insulin secretion; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; spinal cord motor neuron differentiation; positive regulation of interleukin-1 beta production; negative regulation of neuron differentiation; positive regulation of interferon-gamma production; positive regulation of angiogenesis; mesenchymal cell differentiation; visceral motor neuron differentiation; pituitary gland development; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; peripheral nervous system neuron axonogenesis; retinal ganglion cell axon guidance
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 Research Articles on ISL1    1. ISL-1 is tightly linked to non-Hodgkin lymphoma proliferation and development by promoting c-Myc transcription, and its aberrant expression was regulated by p-STAT3/p-c-Jun/ISL-1 complex activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ISL1 antibodyPathways associated with anti-ISL1 antibody
 Reference Product  PubMed Publications
 NKX2-5 antibody  >46 publications with ISL1 and NKX2-5
 NKX6-1 antibody  >23 publications with ISL1 and NKX6-1
 MEF2C antibody  >17 publications with ISL1 and MEF2C
 SHH antibody  >16 publications with ISL1 and SHH
 BMP4 antibody  >12 publications with ISL1 and BMP4
 FGF10 antibody  >10 publications with ISL1 and FGF10
 FGF8 antibody  >9 publications with ISL1 and FGF8
 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Incretin Synthesis, Secretion, And Inactivation Pathway antibodies  Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway antibodies  Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway Diagram
Diseases associated with anti-ISL1 antibodyOrgans/Tissues associated with anti-ISL1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >35 publications with ISL1 and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >31 publications with ISL1 and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >26 publications with ISL1 and Heart Defects, Congenital
 Cardiovascular Abnormalities Antibodies  >22 publications with ISL1 and Cardiovascular Abnormalities
 Embryo Loss Antibodies  >13 publications with ISL1 and Embryo Loss
 Carcinoma Antibodies  >13 publications with ISL1 and Carcinoma
 Nervous System Diseases Antibodies  >11 publications with ISL1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >5 publications with ISL1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >5 publications with ISL1 and Breast Neoplasms
 Diabetes Mellitus, Type 2 Antibodies  >5 publications with ISL1 and Diabetes Mellitus, Type 2
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >121 publications with ISL1 and Embryonic Tissue
 Muscle Antibodies  >107 publications with ISL1 and Muscle
 Pancreas Antibodies  >63 publications with ISL1 and Pancreas
 Brain Antibodies  >56 publications with ISL1 and Brain
 Eye Antibodies  >45 publications with ISL1 and Eye
 Lung Antibodies  >12 publications with ISL1 and Lung
 Intestine Antibodies  >6 publications with ISL1 and Intestine
 Stomach Antibodies  >6 publications with ISL1 and Stomach
 Kidney Antibodies  >3 publications with ISL1 and Kidney
 Umbilical Cord Antibodies  >2 publications with ISL1 and Umbilical Cord
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