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anti-IgA antibody :: Mouse IgA Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS213033
Testing Data
Unit / Price
0.2 mg  /  $415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IgA, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN IgA HEAVY CHAIN

 Product Gene Name   

anti-IgA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146900
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    Mc24-2E11
 Host    Mouse
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 Specificity    This item recognises human immunoglobulin alpha heavy chains. No cross reactivity observed with IgG, IgM or free kappa and lambda light chains.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Immunogen    Reduced and alkylated human IgA
Fusion Partners
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-IgA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IgA antibody

   MBS213033 recognises human immunoglobulin alpha heavy chains. No cross reactivity observed with IgG, IgM or free kappa and lambda light chains.
 Applications Tested/Suitable for anti-IgA antibody   

Immunohistology Frozen, ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

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 Testing Data of anti-IgA antibody    Sandwich ELISA analysis of human IgA binding using Mouse anti Human IgA as a capture reagent and biotinylated Mouse anti Human IgA (MBS211704) as a detection reagent with purified human IgA (MBS230288) as antigen. Subsequent detection is by HRP conjugated streptavidin and substrate. Microtitre plate is read at O.D. 450 nm on the iMark Microplate Absorbance Reader . Serum sample is displayed at 25000 (Blue) and 50000 (Red) fold dilutions
anti-IgA antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for IgA. It may not necessarily be applicable to this product.
 NCBI GI #    113584
 NCBI GeneID    3493
 NCBI Accession #    P01876.2 [Other Products]
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 UniProt Related Accession #    P01876 [Other Products]
 Molecular Weight    37,655 Da
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 NCBI Official Full Name    Ig alpha-1 chain C region, partial
 NCBI Official Synonym Full Names    immunoglobulin heavy constant alpha 1
 NCBI Official Symbol    IGHA1 [Similar Products]
 NCBI Official Synonym Symbols   
IgA1
[Similar Products]
 UniProt Protein Name    Ig alpha-1 chain C region
 Protein Family    IgA receptor
 UniProt Gene Name    IGHA1 [Similar Products]
 UniProt Entry Name    IGHA1_HUMAN
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 UniProt Comments for IgA    IGHA1: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Protein type: Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: extracellular space; extracellular region

Molecular Function: antigen binding

Biological Process: receptor-mediated endocytosis; retinal homeostasis; glomerular filtration; antibacterial humoral response; immune response; protein-chromophore linkage
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 Research Articles on IgA    1. The heritability of IgA levels is moderate and can partly be attributable to common variation in the CD30L locus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-IgA antibodyOrgans/Tissues associated with anti-IgA antibody
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with IgA and Blood
 Brain Antibodies  >1 publications with IgA and Brain
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