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anti-IgG1 antibody :: Mouse anti-Human Immunoglobulin G1 (IgG1) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2090591
Western Blot (WB)
Unit / Price
0.01 mg  /  $100 +1 FREE 8GB USB
0.02 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $175 +1 FREE 8GB USB
0.2 mg  /  $225 +1 FREE 8GB USB
1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Immunoglobulin G1 (IgG1), Monoclonal Antibody

 Also Known As   

Monoclonal Antibody to Immunoglobulin G1 (IgG1)

 Product Synonym Names    IGHG1; Ig Gamma-1 Chain C Region; Immunoglobulin Heavy Constant Gamma 1; G1m Marker; Immunoglobulin Gm1
 Product Gene Name   

anti-IgG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    J00228 Genomic DNA
 3D Structure    ModBase 3D Structure for P01857
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 Clonality    Monoclonal
 Isotype    IgG2b Kappa
 Clone Number    C4
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against IgG1. It has been selected for its ability to recognize IgG1 in immunohistochemical staining and western blotting.
 Purity/Purification    Protein A + Protein G affinity chromatography
 Form/Format    Liquid
 Concentration    1mg/mL (lot specific)
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 Immunogen    Native Immunoglobulin G1 (IgG1)
 Buffer Formulation    0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-IgG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IgG1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

 Application Notes for anti-IgG1 antibody    Western Blot: 0.5-5ug/mL
Immunohistochemistry: 5-30ug/mL
Immunocytochemistry: 5-30ug/mL
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 Western Blot (WB) of anti-IgG1 antibody    (Western Blot; Sample: Human Serum; Primary Ab: 150 Mouse Anti-Human IgG1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody )
anti-IgG1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IgG1. It may not necessarily be applicable to this product.
 NCBI GI #    121039
 NCBI GeneID    3500
 NCBI Accession #    P01857.1 [Other Products]
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 UniProt Primary Accession #    P01857 [Other Products]
 UniProt Related Accession #    P01857 [Other Products]
 Molecular Weight    36,106 Da
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 NCBI Official Full Name    Immunoglobulin heavy constant gamma 1
 NCBI Official Synonym Full Names    immunoglobulin heavy constant gamma 1 (G1m marker)
 NCBI Official Symbol    IGHG1 [Similar Products]
 UniProt Protein Name    Immunoglobulin heavy constant gamma 1
 UniProt Synonym Protein Names   
Ig gamma-1 chain C region
 UniProt Gene Name    IGHG1 [Similar Products]
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 UniProt Comments for IgG1    IGHG1: Defects in IGHG1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Protein type: Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: external side of plasma membrane; extracellular region; extracellular space

Molecular Function: antigen binding; protein binding; serine-type endopeptidase activity

Biological Process: B cell receptor signaling pathway; complement activation; complement activation, classical pathway; defense response to bacterium; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of B cell activation; proteolysis; regulation of complement activation

Disease: Myeloma, Multiple
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 Research Articles on IgG1    1. Our results show that immunoglobulin GM genes are risk factors for the development of schizophrenia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IgG1 antibodyPathways associated with anti-IgG1 antibody
 Reference Product  PubMed Publications
 IGKC antibody  >1 publications with IgG1 and IGKC
 Products by Pathway  Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway antibodies  Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway Diagram
Organs/Tissues associated with anti-IgG1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with IgG1 and Blood
 Lymph Antibodies  >2 publications with IgG1 and Lymph
 Lymph Node Antibodies  >2 publications with IgG1 and Lymph Node
 Intestine Antibodies  >2 publications with IgG1 and Intestine
 Skin Antibodies  >2 publications with IgG1 and Skin
 Bone Antibodies  >1 publications with IgG1 and Bone
 Bone Marrow Antibodies  >1 publications with IgG1 and Bone Marrow
 Thyroid Antibodies  >1 publications with IgG1 and Thyroid
 Pancreas Antibodies  >1 publications with IgG1 and Pancreas
 Uterus Antibodies  >1 publications with IgG1 and Uterus
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