Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow INS rightarrow Monoclonal INS  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Rabbit anti Chicken IgY (H + L) (Alk Phos) Secondary Antibody
 • Prekallikrein, Clone 10G3 (KLK1) Antibody
 • anti-deoxyribonuclease B antibody (anti-DNase B Ab) ELISA Kit
 • Collagen Type II Alpha 1 (COL2a1) Recombinant Protein
 • Osteoprotegerin (OPG) ELISA Kit
 • IgA ELISA Kit
 • SCIN Antibody
 • RDX Antibody
 • CD31 (pY713) (PECAM1) Antibody
 • ATM Antibody
 • C1 Esterase Inhibitor (SERPING1) Antibody
 • PAFAH1B1 - LIS1 Antibody
 • IL2RA (CD25) Recombinant Protein
 • GroES Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-INS antibody :: Mouse Insulin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190241 anti-INS antibody
Unit / Price
0.2 mg  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin, Monoclonal Antibody

 Also Known As   

Human Insulin Monoclonal Antibody

 Product Synonym Names    Anti-Insulin; Insulin
 Product Gene Name   

anti-INS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 11; NC_000011.9 (2181009..2182439, complement). Location: 11p15.5
 OMIM    125852
 3D Structure    ModBase 3D Structure for P01308
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Host    Mouse
Section Bar
 Specificity    Anti-Insulin [Murine MAbs recognize human insulin; 20801 cross-reacts with bovine and porcine insulin (3 clones).]
All three antibodies recognize human insulin and cross-react with human proinsulin, bovine insulin, and porcine insulin.
This product (D4B8) Kd = 1.5 x 10^-8 M.
 Form/Format    200 ug Protein A-purified antibody in PBS, pH 7.4.
Section Bar
 Antigen    Purified human insulin.
 Stabilizer    None
 Preservatives    0.1% sodium azide.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
Section Bar
 Preparation and Storage    These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of anti-INS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-INS antibody    Hormone and Serum Protein Antibodies
 Applications Tested/Suitable for anti-INS antibody   

ELISA, Immunoassay, Immunohistochemistry

 Application Notes for anti-INS antibody    These antibodies may be used in immunoassays to detect and quantitate human insulin. 20802 and 20803 may be used as an antibody pair in a two-site ELISA. 20802 may be used in immunohistochemistry on frozen sections. Not all applications have been investigated.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for INS. It may not necessarily be applicable to this product.
 NCBI GI #    386828
 NCBI GeneID    3630
 NCBI Accession #    AAA59172.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P01308 [Other Products]
 UniProt Secondary Accession #    Q5EEX2 [Other Products]
 UniProt Related Accession #    P01308 [Other Products]
 Molecular Weight    11,981 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    insulin
 NCBI Official Synonym Full Names    insulin
 NCBI Official Symbol    INS [Similar Products]
 NCBI Official Synonym Symbols   
ILPR; IRDN; IDDM2; MODY10
[Similar Products]
 NCBI Protein Information    insulin; proinsulin; OTTHUMP00000011161; OTTHUMP00000011162; OTTHUMP00000196036; OTTHUMP00000196038; OTTHUMP00000217519
 UniProt Protein Name    Insulin
 Protein Family    Insulin
 UniProt Gene Name    INS [Similar Products]
 UniProt Entry Name    INS_HUMAN
Section Bar
 NCBI Summary for INS    After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Section Bar
 UniProt Comments for INS    Insulin: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds. Belongs to the insulin family.

Protein type: Secreted, signal peptide; Secreted; Hormone

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; extracellular region

Molecular Function: insulin-like growth factor receptor binding; identical protein binding; protein binding; protease binding; hormone activity; insulin receptor binding

Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of vasodilation; glucose homeostasis; activation of NF-kappaB transcription factor; negative regulation of protein oligomerization; positive regulation of glucose import; regulation of protein localization; cell-cell signaling; negative regulation of gluconeogenesis; acute-phase response; regulation of transmembrane transporter activity; negative regulation of NAD(P)H oxidase activity; positive regulation of mitosis; positive regulation of nitric-oxide synthase activity; activation of protein kinase B; negative regulation of acute inflammatory response; glucose metabolic process; positive regulation of lipid biosynthetic process; positive regulation of protein amino acid autophosphorylation; positive regulation of cell growth; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell differentiation; negative regulation of protein catabolic process; regulation of amino acid metabolic process; negative regulation of glycogen catabolic process; wound healing; positive regulation of glycogen biosynthetic process; positive regulation of cellular protein metabolic process; glucose transport; regulation of protein secretion; negative regulation of vasodilation; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; negative regulation of lipid catabolic process; positive regulation of cell proliferation; negative regulation of proteolysis; negative regulation of protein secretion; MAPKKK cascade; alpha-beta T cell activation; negative regulation of fatty acid metabolic process; endocrine pancreas development; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; cellular protein metabolic process; fatty acid homeostasis; positive regulation of glycolysis; energy reserve metabolic process; insulin receptor signaling pathway; positive regulation of insulin receptor signaling pathway; regulation of insulin secretion; positive regulation of DNA replication; positive regulation of cell migration; positive regulation of cytokine secretion

Disease: Diabetes Mellitus, Insulin-dependent, 2; Diabetes Mellitus, Permanent Neonatal; Hyperproinsulinemia; Maturity-onset Diabetes Of The Young, Type 10
Table BarTOPTable Bar
 Research Articles on INS    1. Studies indicate that T1DM can be detected by determining four autoantibodies, namely those antibodies against insulin, glutamic acid decarboxylase 65, insulinoma antigen (IA)-2 (ICA512) and the zinc transporter ZnT8.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-INS antibodyPathways associated with anti-INS antibody
 Reference Product  PubMed Publications
 HLA-DQB1 antibody  >25 publications with INS and HLA-DQB1
 INSR antibody  >18 publications with INS and INSR
 IGF1R antibody  >16 publications with INS and IGF1R
 GCK antibody  >15 publications with INS and GCK
 IDE antibody  >5 publications with INS and IDE
 SYTL4 antibody  >2 publications with INS and SYTL4
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
Diseases associated with anti-INS antibodyOrgans/Tissues associated with anti-INS antibody
 Disease Name  Pubmed Publications
 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules Antibodies  >2426 publications with INS and Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules
 Neoplasms Antibodies  >807 publications with INS and Neoplasms
 Diabetes Mellitus Antibodies  >629 publications with INS and Diabetes Mellitus
 Cardiovascular Diseases Antibodies  >269 publications with INS and Cardiovascular Diseases
 Kidney Diseases Antibodies  >258 publications with INS and Kidney Diseases
 Diabetes Mellitus, Type 1 Antibodies  >242 publications with INS and Diabetes Mellitus, Type 1
 Pancreatic Neoplasms Antibodies  >241 publications with INS and Pancreatic Neoplasms
 Insulin Resistance Antibodies  >240 publications with INS and Insulin Resistance
 Adenoma Antibodies  >237 publications with INS and Adenoma
 Diabetes Mellitus, Type 2 Antibodies  >203 publications with INS and Diabetes Mellitus, Type 2
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1239 publications with INS and Blood
 Pancreas Antibodies  >1145 publications with INS and Pancreas
 Brain Antibodies  >613 publications with INS and Brain
 Muscle Antibodies  >492 publications with INS and Muscle
 Liver Antibodies  >320 publications with INS and Liver
 Heart Antibodies  >246 publications with INS and Heart
 Vascular Antibodies  >227 publications with INS and Vascular
 Kidney Antibodies  >212 publications with INS and Kidney
 Nerve Antibodies  >203 publications with INS and Nerve
 Bone Antibodies  >131 publications with INS and Bone
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions