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anti-INS antibody :: anti-Human Insulin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS312647 anti-INS antibody
Unit / Price
1 mg  /  $495 +1 FREE 8GB USB
 
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 Product Name   

Insulin, Monoclonal Antibody

★Popular Item★
 Also Known As   

MAb to Insulin

 Product Synonym Names    Monoclonal Antibody to Human Insulin
 Product Gene Name   

anti-INS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (2181009..2182439, complement). Location: 11p15.5
 OMIM    125852
 3D Structure    ModBase 3D Structure for P01308
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    7F5
 Host    Host: Mouse. Hybridization of X63-Ag8-653 myeloma cells with spleen cells from Balb/c mice.
Source: Ascites
 Species Reactivity    Human
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 Specificity    Insulin
Human insulin. Cross reacts with human proinsulin, bovine insulin (30%) and porcine insulin. Does not cross react with free C-peptide.
 Purity/Purification    >90% pure (SDS-PAGE). Protein A chromatography
 Form/Format    Purified, Liquid
 Concentration    7.2mg/ml (OD280nm, E^0.1% = 1.4) (lot specific)
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 Immunogen    Purified Human insulin
 Affinity Constant    Kass = 1.0 x 10^9 M^-1
 Buffer    PBS, pH 7.4
 Preservative    0.1% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Store at 2 to 8 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-INS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-INS antibody    Monoclonal Antibodies to Hormones and Steroids
 Applications Tested/Suitable for anti-INS antibody   

EIA/ELISA

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NCBI/Uniprot data below describe general gene information for INS. It may not necessarily be applicable to this product.
 NCBI GI #    386828
 NCBI GeneID    3630
 NCBI Accession #    AAA59172.1 [Other Products]
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 UniProt Primary Accession #    P01308 [Other Products]
 UniProt Secondary Accession #    Q5EEX2 [Other Products]
 UniProt Related Accession #    P01308 [Other Products]
 Molecular Weight    11,981 Da [Similar Products]
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 NCBI Official Full Name    insulin
 NCBI Official Synonym Full Names    insulin
 NCBI Official Symbol    INS [Similar Products]
 NCBI Official Synonym Symbols   
ILPR; IRDN; IDDM2; MODY10
[Similar Products]
 NCBI Protein Information    insulin; proinsulin; OTTHUMP00000011161; OTTHUMP00000011162; OTTHUMP00000196036; OTTHUMP00000196038; OTTHUMP00000217519
 UniProt Protein Name    Insulin
 Protein Family    Insulin
 UniProt Gene Name    INS [Similar Products]
 UniProt Entry Name    INS_HUMAN
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 NCBI Summary for INS    After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
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 UniProt Comments for INS    Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Subunit structure: Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Subcellular location: Secreted.

Involvement in disease: Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [

MIM:176730]. Ref.21 Ref.23 Ref.24 Ref.25Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [

MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Ref.34Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [

MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Ref.32 Ref.33Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [

MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Ref.33 Ref.34 Ref.35

Pharmaceutical use: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.

Sequence similarities: Belongs to the insulin family.

Sequence caution: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
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 Research Articles on INS    1. Studies indicate that T1DM can be detected by determining four autoantibodies, namely those antibodies against insulin, glutamic acid decarboxylase 65, insulinoma antigen (IA)-2 (ICA512) and the zinc transporter ZnT8.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-INS antibodyPathways associated with anti-INS antibody
 Reference Product  PubMed Publications
 HLA-DQB1 antibody  >25 publications with INS and HLA-DQB1
 INSR antibody  >18 publications with INS and INSR
 IGF1R antibody  >16 publications with INS and IGF1R
 GCK antibody  >15 publications with INS and GCK
 IDE antibody  >5 publications with INS and IDE
 SYTL4 antibody  >2 publications with INS and SYTL4
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
Diseases associated with anti-INS antibodyOrgans/Tissues associated with anti-INS antibody
 Disease Name  Pubmed Publications
 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules Antibodies  >2426 publications with INS and Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules
 Neoplasms Antibodies  >807 publications with INS and Neoplasms
 Diabetes Mellitus Antibodies  >629 publications with INS and Diabetes Mellitus
 Cardiovascular Diseases Antibodies  >269 publications with INS and Cardiovascular Diseases
 Kidney Diseases Antibodies  >258 publications with INS and Kidney Diseases
 Diabetes Mellitus, Type 1 Antibodies  >242 publications with INS and Diabetes Mellitus, Type 1
 Pancreatic Neoplasms Antibodies  >241 publications with INS and Pancreatic Neoplasms
 Insulin Resistance Antibodies  >240 publications with INS and Insulin Resistance
 Adenoma Antibodies  >237 publications with INS and Adenoma
 Diabetes Mellitus, Type 2 Antibodies  >203 publications with INS and Diabetes Mellitus, Type 2
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1239 publications with INS and Blood
 Pancreas Antibodies  >1145 publications with INS and Pancreas
 Brain Antibodies  >613 publications with INS and Brain
 Muscle Antibodies  >492 publications with INS and Muscle
 Liver Antibodies  >320 publications with INS and Liver
 Heart Antibodies  >246 publications with INS and Heart
 Vascular Antibodies  >227 publications with INS and Vascular
 Kidney Antibodies  >212 publications with INS and Kidney
 Nerve Antibodies  >203 publications with INS and Nerve
 Bone Antibodies  >131 publications with INS and Bone
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