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anti-INS antibody :: Mouse Insulin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531719 anti-INS antibody
Unit / Price
1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin, Monoclonal Antibody

 Also Known As   

Insulin antibody

 Product Synonym Names    Monoclonal Insulin; Anti-Insulin
 Product Gene Name   

anti-INS antibody

[Similar Products]
 Matching Pairs    Capture Antibody: Insulin Clone #M322213 (MBS531836)
Detection Antibody: Insulin Clone #M322214 (MBS531719)
Comments: Recommended for ELISA & IHC on frozen sections
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    125852
 3D Structure    ModBase 3D Structure for P01308
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    M322214
 Host    Mouse
 Species Reactivity    Insulin: 100%
Human ProInsulin: 1%
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 Specificity    Human
 Purity/Purification    Insulin antibody was purified by chromatography on protein A Sepharose.
 Form/Format    Protein A purified and supplied in PBS buffer, pH 7.4 containing 0.09% NaN3
 Concentration    8.6 mg/ml (lot specific)
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 Immunogen    Purified human insulin
 Affinity Constant    ~2 x 108 Liters/mole
 Biological Significance    insulin, a hormone that regulates the level of sugar (glucose) in the blood and that is produced by the beta cells of the islets of Langerhans in the pancreas. Insulin is secreted when the level of blood glucose rises such as after a meal. When the level of blood glucose falls, secretion of insulin stops, and the liver releases glucose into the blood.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
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 Preparation and Storage    Store at 4C short term, -20C long term
 Other Notes    Small volumes of anti-INS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-INS antibody

   Mouse monoclonal Insulin antibody
 Product Categories/Family for anti-INS antibody    Hormones & Steroids
 Applications Tested/Suitable for anti-INS antibody   

ELISA (EIA), two site immunoassay

 Application Notes for anti-INS antibody    We recommend MBS531836 clone M322213 as the solid phase and MBS531719 clone M322214 as the sandwich label ELISA. Also suitable for two site immunoassay.

Optimal conditions to be determined by end user.
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NCBI/Uniprot data below describe general gene information for INS. It may not necessarily be applicable to this product.
 NCBI GI #    386828
 NCBI GeneID    3630
 NCBI Accession #    AAA59172.1 [Other Products]
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 UniProt Primary Accession #    P01308 [Other Products]
 UniProt Secondary Accession #    Q5EEX2 [Other Products]
 UniProt Related Accession #    P01308 [Other Products]
 Molecular Weight    21,537 Da [Similar Products]
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 NCBI Official Full Name    insulin
 NCBI Official Synonym Full Names    insulin
 NCBI Official Symbol    INS [Similar Products]
 NCBI Official Synonym Symbols   
IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
[Similar Products]
 NCBI Protein Information    insulin
 UniProt Protein Name    Insulin
 Protein Family    Insulin
 UniProt Gene Name    INS [Similar Products]
 UniProt Entry Name    INS_HUMAN
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 NCBI Summary for INS    After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
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 UniProt Comments for INS    Insulin: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds. Belongs to the insulin family.

Protein type: Secreted; Secreted, signal peptide; Hormone

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; extracellular region

Molecular Function: insulin-like growth factor receptor binding; identical protein binding; protein binding; protease binding; hormone activity; insulin receptor binding

Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of vasodilation; glucose homeostasis; activation of NF-kappaB transcription factor; positive regulation of glucose import; negative regulation of protein oligomerization; regulation of protein localization; cell-cell signaling; negative regulation of gluconeogenesis; acute-phase response; regulation of transmembrane transporter activity; negative regulation of NAD(P)H oxidase activity; positive regulation of mitosis; positive regulation of nitric-oxide synthase activity; activation of protein kinase B; negative regulation of acute inflammatory response; glucose metabolic process; positive regulation of lipid biosynthetic process; positive regulation of cell growth; positive regulation of protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of peptidyl-tyrosine phosphorylation; regulation of amino acid metabolic process; positive regulation of cell differentiation; negative regulation of protein catabolic process; negative regulation of glycogen catabolic process; wound healing; positive regulation of glycogen biosynthetic process; positive regulation of cellular protein metabolic process; glucose transport; regulation of protein secretion; negative regulation of lipid catabolic process; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; negative regulation of vasodilation; positive regulation of cell proliferation; negative regulation of proteolysis; negative regulation of protein secretion; MAPKKK cascade; negative regulation of fatty acid metabolic process; alpha-beta T cell activation; endocrine pancreas development; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; cellular protein metabolic process; fatty acid homeostasis; positive regulation of glycolysis; energy reserve metabolic process; insulin receptor signaling pathway; positive regulation of insulin receptor signaling pathway; regulation of insulin secretion; positive regulation of DNA replication; positive regulation of cell migration; positive regulation of cytokine secretion

Disease: Diabetes Mellitus, Insulin-dependent, 2; Diabetes Mellitus, Permanent Neonatal; Hyperproinsulinemia; Maturity-onset Diabetes Of The Young, Type 10
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 Research Articles on INS    1. individuals with PTSD had a hyperinsulinemic response to oral glucose challenge compared to controls, suggestive of insulin resistance.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-INS antibodyPathways associated with anti-INS antibody
 Reference Product  PubMed Publications
 PDX1 antibody  >61 publications with INS and PDX1
 IRS1 antibody  >38 publications with INS and IRS1
 FOXO1 antibody  >35 publications with INS and FOXO1
 INSR antibody  >33 publications with INS and INSR
 IRS2 antibody  >30 publications with INS and IRS2
 IGF1R antibody  >24 publications with INS and IGF1R
 AKT1 antibody  >18 publications with INS and AKT1
 IGFBP1 antibody  >8 publications with INS and IGFBP1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
Diseases associated with anti-INS antibodyOrgans/Tissues associated with anti-INS antibody
 Disease Name  Pubmed Publications
 Metabolic Diseases Antibodies  >1163 publications with INS and Metabolic Diseases
 Diabetes Mellitus Antibodies  >969 publications with INS and Diabetes Mellitus
 Insulin Resistance Antibodies  >346 publications with INS and Insulin Resistance
 Diabetes Mellitus, Type 2 Antibodies  >332 publications with INS and Diabetes Mellitus, Type 2
 Obesity Antibodies  >261 publications with INS and Obesity
 Hyperglycemia Antibodies  >237 publications with INS and Hyperglycemia
 Hyperinsulinism Antibodies  >225 publications with INS and Hyperinsulinism
 Hypertension Antibodies  >135 publications with INS and Hypertension
 Polycystic Ovary Syndrome Antibodies  >60 publications with INS and Polycystic Ovary Syndrome
 Hypoglycemia Antibodies  >53 publications with INS and Hypoglycemia
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >1632 publications with INS and Pancreas
 Blood Antibodies  >1602 publications with INS and Blood
 Brain Antibodies  >821 publications with INS and Brain
 Muscle Antibodies  >577 publications with INS and Muscle
 Liver Antibodies  >429 publications with INS and Liver
 Heart Antibodies  >316 publications with INS and Heart
 Kidney Antibodies  >291 publications with INS and Kidney
 Nerve Antibodies  >290 publications with INS and Nerve
 Vascular Antibodies  >288 publications with INS and Vascular
 Bone Antibodies  >169 publications with INS and Bone
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