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anti-ITGB1 antibody :: Mouse Integrin beta 1D Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS570164
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin beta 1D (ITGB1), Monoclonal Antibody

 Also Known As   

Mouse anti Integrin beta 1D

 Product Gene Name   

anti-ITGB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (33189246..33247293, complement). Location: 10p11.2
 OMIM    135630
 3D Structure    ModBase 3D Structure for P05556
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2B1
 Host    Mouse
 Species Reactivity    Canine, Human, Mouse, Swine
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 Specificity    2B1 recognizes specifically the cytoplasmic domain of integrin subunit beta1D present in cardiac and skeletal muscle.
 Form/Format    Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
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 Source Note    2B1 is a Mouse monoclonal IgG1, kappa antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a Mouse immunized with a synthetic peptide corresponding to the C-terminal 24 amino acids of integrin beta1D including an appending N-terminal cysteine (CQENPIYKS-PINNFKNPNYGRKAGL) coupled to keyhole limpet hemocyanin.
 Reactivity Note    A broad species reactivity is expected because of the conserved nature of the epitope.
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 Preparation and Storage    Store at 4 degree C, or in small aliquots at -20 degree C.
 Other Notes    Small volumes of anti-ITGB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ITGB1 antibody

   Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migRation and apoptosis. There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids. Their distribution pattern in adult tissues is mutually exclusive. beta1A is present in all tissues, except cardiac and skeletal muscle, which instead express the beta1D variant.
 Product Categories/Family for anti-ITGB1 antibody    Cell adhesion, Cardiovascular, Cell adhesion
 Applications Tested/Suitable for anti-ITGB1 antibody   

Immunocytochemistry (IHC), Immunohistochemistry (IHC) (frozen), Western Blot (WB)

 Application Notes for anti-ITGB1 antibody    2B1 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen tissues. Optimal antibody dilution should be determined by titRation; recommended range is 1:25 - 1:200 for immunohistochemistry with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting appliCations.
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 Testing Data of anti-ITGB1 antibody    Fig.1: Frozen sections of porcine myocardium immunostained for integrin β1D using a 1:200 dillution of 2B1
anti-ITGB1 antibody Testing Data image
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 Testing Data of anti-ITGB1 antibody    Fig.2: Negative control: only secondary antibody applied.
anti-ITGB1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ITGB1. It may not necessarily be applicable to this product.
 NCBI GI #    19743819
 NCBI GeneID    3688
 NCBI Accession #    NP_391988.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_033668.2 [Other Products]
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 UniProt Primary Accession #    P05556 [Other Products]
 UniProt Secondary Accession #    P78466; P78467; Q13089; Q13090; Q13091; Q13212; A8K6N2; D3DRX9; D3DRY3; D3DRY4; D3DRY5 [Other Products]
 UniProt Related Accession #    P05556 [Other Products]
 Molecular Weight    88,415 Da [Similar Products]
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 NCBI Official Full Name    integrin beta-1 isoform 1D
 NCBI Official Synonym Full Names    integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
 NCBI Official Symbol    ITGB1 [Similar Products]
 NCBI Official Synonym Symbols   
CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA
[Similar Products]
 NCBI Protein Information    integrin beta-1; glycoprotein IIa; integrin VLA-4 beta subunit; very late activation protein, beta polypeptide
 UniProt Protein Name    Integrin beta-1
 UniProt Synonym Protein Names   
Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta
 Protein Family    Integrin
 UniProt Gene Name    ITGB1 [Similar Products]
 UniProt Synonym Gene Names    FNRB; MDF2; MSK12; GPIIA [Similar Products]
 UniProt Entry Name    ITB1_HUMAN
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 NCBI Summary for ITGB1    Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ITGB1    ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. . Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle).

Protein type: Membrane protein, integral; Cell adhesion; Cell surface; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 10p11.2

Cellular Component: focal adhesion; cell surface; dendritic spine; acrosome; lipid raft; ruffle; recycling endosome; hemidesmosome; membrane; lamellipodium; cytoplasm; plasma membrane; melanosome; basement membrane; integrin complex; neuromuscular junction; receptor complex; sarcolemma; cleavage furrow; filopodium; external side of plasma membrane

Molecular Function: protein domain specific binding; protease binding; metal ion binding; laminin binding; actin binding; alpha-actinin binding; peptide binding; protein kinase binding; integrin binding; viral receptor activity; protein binding; protein heterodimerization activity; fibronectin binding; cell adhesion molecule binding; glycoprotein binding

Biological Process: extracellular matrix organization and biogenesis; maternal process involved in pregnancy; regulation of cell cycle; positive regulation of apoptosis; axon extension; mesodermal cell differentiation; positive regulation of endocytosis; cardiac muscle cell differentiation; leukocyte adhesion; transforming growth factor beta receptor signaling pathway; germ cell migration; tissue homeostasis; response to drug; dendrite morphogenesis; protein transport within lipid bilayer; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of neuron differentiation; cell migration during sprouting angiogenesis; B cell differentiation; cell-cell adhesion mediated by integrin; response to activity; leukocyte migration; regulation of G-protein coupled receptor protein signaling pathway; G1/S transition of mitotic cell cycle; axon guidance; entry of virus into host cell; cell-matrix adhesion; cell fate specification; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; visual learning; negative regulation of cell projection organization and biogenesis; integrin-mediated signaling pathway; cell migration; regulation of immune response; in utero embryonic development; sarcomere organization; cell-substrate adhesion; formation of radial glial scaffolds; cellular calcium ion homeostasis; heterotypic cell-cell adhesion; negative regulation of Rho protein signal transduction; calcium-independent cell-matrix adhesion; stress fiber formation; cellular defense response; blood coagulation; leukocyte tethering or rolling; homophilic cell adhesion; positive regulation of cell migration
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Product References and Citations for anti-ITGB1 antibody

   van der Flier, A., Gaspar, A. C., Thorsteinsdottir, S., Baudoin, C., Groeneveld, E., Mummery, C. L., and Sonnenberg, A. (1997). Spatial and temporal expression of the beta1D integrin during Mouse development, Dev Dyn 210, 472-86.
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 Research Articles on ITGB1    1. beta-1,4-Galactosyltransferase III enhances invasive phenotypes via beta1-integrin and predicts poor prognosis in neuroblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ITGB1 antibodyDiseases associated with anti-ITGB1 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >28 publications with ITGB1 and Neoplasms
 Carcinoma Antibodies  >12 publications with ITGB1 and Carcinoma
 Neoplasm Invasiveness Antibodies  >8 publications with ITGB1 and Neoplasm Invasiveness
 Nervous System Diseases Antibodies  >7 publications with ITGB1 and Nervous System Diseases
 Inflammation Antibodies  >6 publications with ITGB1 and Inflammation
 Lung Diseases Antibodies  >5 publications with ITGB1 and Lung Diseases
 Fibrosis Antibodies  >4 publications with ITGB1 and Fibrosis
 Cardiovascular Diseases Antibodies  >4 publications with ITGB1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >3 publications with ITGB1 and Kidney Diseases
 Necrosis Antibodies  >3 publications with ITGB1 and Necrosis
Organs/Tissues associated with anti-ITGB1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with ITGB1 and Blood
 Brain Antibodies  >14 publications with ITGB1 and Brain
 Vascular Antibodies  >11 publications with ITGB1 and Vascular
 Bone Antibodies  >10 publications with ITGB1 and Bone
 Muscle Antibodies  >8 publications with ITGB1 and Muscle
 Embryonic Tissue Antibodies  >8 publications with ITGB1 and Embryonic Tissue
 Lung Antibodies  >7 publications with ITGB1 and Lung
 Uterus Antibodies  >6 publications with ITGB1 and Uterus
 Liver Antibodies  >6 publications with ITGB1 and Liver
 Kidney Antibodies  >6 publications with ITGB1 and Kidney
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