NP_001034343.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
integrin beta-1
NCBI Protein Information
integrin beta-1; CSAT antigen; JG22 antigen; RGD-receptor
UniProt Protein Name
Integrin beta-1
UniProt Synonym Protein Names
CSAT antigen; JG22 antigen; RGD-receptor
UniProt Entry Name
ITB1_CHICK
UniProt Comments for ITGB1
ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. . Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle).
Protein type: Membrane protein, integral; Cell surface; Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc.
Cellular Component: lamellipodium; melanosome; plasma membrane; integrin complex; cell junction
Molecular Function: protein binding; metal ion binding; receptor activity
Biological Process: integrin-mediated signaling pathway; cell-matrix adhesion; multicellular organismal development
Research Articles on ITGB1
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Pathways associated with anti-ITGB1 antibody
Organs/Tissues associated with anti-ITGB1 antibody
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