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anti-ITGB1 antibody :: Mouse anti-Human Integrin beta1, Adhesion Stimulating Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS602058 anti-ITGB1 antibody
Unit / Price
0.1 mg  /  $655 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin beta1, Adhesion Stimulating (ITGB1), Monoclonal Antibody

★Popular Item★
 Also Known As   

Integrin beta1, Adhesion Stimulating

 Product Synonym Names    Anti -Integrin beta1, Adhesion Stimulating
 Product Gene Name   

anti-ITGB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_006089.2 (13960079..14001480)
 3D Structure    ModBase 3D Structure for P07228
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2Q829
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Reacts with the human integrin beta 1 subunit. Specificity verified by preclearing of beta 1 in immunoprecipitation, flow cytometry on transfectant cells displaying human beta 1 integrin and reactivity with purified beta 1.
 Purity/Purification    Affinity Purified
Purified immunoglobulin from Protein A Sepharose chromatography
 Form/Format    Supplied as a liquid in 0.02M PB,pH 7.6, 0.25M sodium chloride containing 0.1% sodium azide
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 Immunogen    Human synovial cells
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 Preparation and Storage    Maintain at 2-8 degree C in undiluted aliquots for up to 12 months
 Other Notes    Small volumes of anti-ITGB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ITGB1 antibody    Antibodies; Abs to Integrin
 Applications Tested/Suitable for anti-ITGB1 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

 Application Notes for anti-ITGB1 antibody    Immunoprecipitation, Immunohistochemistry on frozen sections, Flow cytometry, Blocks adhesion of cells to extracellular matrix proteins, Induces aggregation of certain lymphoid cells, Does not bind reduced beta 1 integrin on Western blot
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NCBI/Uniprot data below describe general gene information for ITGB1. It may not necessarily be applicable to this product.
 NCBI GI #    298231107
 NCBI GeneID    374058
 NCBI Accession #    NP_001034343.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001039254.2 [Other Products]
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 UniProt Primary Accession #    P07228 [Other Products]
 UniProt Related Accession #    P07228; Q8AV89 [Other Products]
 Molecular Weight    88,554 Da [Similar Products]
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 NCBI Official Full Name    integrin beta-1
 NCBI Official Symbol    ITGB1 [Similar Products]
 NCBI Protein Information    integrin beta-1; CSAT antigen; JG22 antigen; RGD-receptor
 UniProt Protein Name    Integrin beta-1
 UniProt Synonym Protein Names   
CSAT antigen; JG22 antigen; RGD-receptor
 Protein Family    Integrin
 UniProt Gene Name    ITGB1 [Similar Products]
 UniProt Entry Name    ITB1_CHICK
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 UniProt Comments for ITGB1    ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. . Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle).

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Receptor, misc.; Cell surface

Cellular Component: lamellipodium; melanosome; plasma membrane; cell junction; integrin complex

Molecular Function: protein binding; metal ion binding; receptor activity

Biological Process: integrin-mediated signaling pathway; cell-matrix adhesion; multicellular organismal development
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 Research Articles on ITGB1    1. Normal fibroblasts promote myodifferentiation of myoblasts from sex-linked dwarf chicken via up-regulation of beta1 integrin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ITGB1 antibodyOrgans/Tissues associated with anti-ITGB1 antibody
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with ITGB1 and Blood
 Brain Antibodies  >7 publications with ITGB1 and Brain
 Muscle Antibodies  >6 publications with ITGB1 and Muscle
 Embryonic Tissue Antibodies  >5 publications with ITGB1 and Embryonic Tissue
 Heart Antibodies  >3 publications with ITGB1 and Heart
 Liver Antibodies  >3 publications with ITGB1 and Liver
 Head Antibodies  >2 publications with ITGB1 and Head
 Spleen Antibodies  >1 publications with ITGB1 and Spleen
 Gonad Antibodies  >1 publications with ITGB1 and Gonad
 Limb Antibodies  >1 publications with ITGB1 and Limb
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