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anti-IRF3 antibody :: Mouse Interferon Regulatory Factor-3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140272 anti-IRF3 antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interferon Regulatory Factor-3 (IRF3), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Interferon Regulatory Factor-3

 Product Synonym Names    IRF3 Antibody; Interferon Regulatory Factor-3, Mouse Anti Human; IRF-3; IRF3; Interferon Regulatory Factor 3
 Product Gene Name   

anti-IRF3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603734
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 Clonality    Monoclonal
 Isotype    IgG1 heavy chain and kappa light chain
 Clone Number    P3F10AT
 Host    Mouse
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 Purity/Purification    IRF3 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sterile Filtered clear solution.
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 Immunogen    Anti-human IRF3 mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human IRF3 amino acids 108-166 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-IRF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IRF3 antibody

   Introduction: Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn
 Product Categories/Family for anti-IRF3 antibody    ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine
 Applications Tested/Suitable for anti-IRF3 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-IRF3 antibody    IRF3 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.
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NCBI/Uniprot data below describe general gene information for IRF3. It may not necessarily be applicable to this product.
 NCBI GI #    308199456
 NCBI GeneID    3661
 NCBI Accession #    NP_001184056.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001197127.1 [Other Products]
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 UniProt Secondary Accession #    Q5FBY1; Q5FBY2; Q5FBY4; Q7Z5G6; A8K7L2; B2RAZ3 [Other Products]
 UniProt Related Accession #    Q14653 [Other Products]
 Molecular Weight    12,330 Da
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 NCBI Official Full Name    interferon regulatory factor 3 isoform 6
 NCBI Official Synonym Full Names    interferon regulatory factor 3
 NCBI Official Symbol    IRF3 [Similar Products]
 NCBI Protein Information    interferon regulatory factor 3
 UniProt Protein Name    Interferon regulatory factor 3
 Protein Family    Interferon regulatory factor
 UniProt Gene Name    IRF3 [Similar Products]
 UniProt Synonym Gene Names    IRF-3 [Similar Products]
 UniProt Entry Name    IRF3_HUMAN
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 NCBI Summary for IRF3    This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
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 UniProt Comments for IRF3    IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; transcription cofactor activity; transcription factor activity

Biological Process: negative regulation of interferon-beta biosynthetic process; transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; cytokine and chemokine mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of defense response to virus by host; toll-like receptor 3 signaling pathway; response to exogenous dsRNA; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon-beta production; positive regulation of interferon type I production; toll-like receptor signaling pathway; innate immune response; interferon type I biosynthetic process; toll-like receptor 4 signaling pathway; defense response to virus; negative regulation of interferon type I production; response to DNA damage stimulus; positive regulation of interferon-alpha production; positive regulation of cytokine secretion

Disease: Herpes Simplex Encephalitis, Susceptibility To, 7
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 Research Articles on IRF3    1. Inhibition of the IRF3 and IRF7 innate immune pathways in patients with atopic dermatitis with a history of eczema herpeticum might be an important mechanism for increased susceptibility to disseminated viral infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRF3 antibodyPathways associated with anti-IRF3 antibody
 Reference Product  PubMed Publications
 TBK1 antibody  >239 publications with IRF3 and TBK1
 JUN antibody  >145 publications with IRF3 and JUN
 MAVS antibody  >102 publications with IRF3 and MAVS
 IRF5 antibody  >41 publications with IRF3 and IRF5
 IKBKE antibody  >28 publications with IRF3 and IKBKE
 IFNB1 antibody  >18 publications with IRF3 and IFNB1
 CREBBP antibody  >15 publications with IRF3 and CREBBP
 PIN1 antibody  >6 publications with IRF3 and PIN1
 EP300 antibody  >6 publications with IRF3 and EP300
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
Diseases associated with anti-IRF3 antibodyOrgans/Tissues associated with anti-IRF3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >194 publications with IRF3 and Inflammation
 Necrosis Antibodies  >146 publications with IRF3 and Necrosis
 Death Antibodies  >68 publications with IRF3 and Death
 Liver Diseases Antibodies  >60 publications with IRF3 and Liver Diseases
 Cardiovascular Diseases Antibodies  >31 publications with IRF3 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >21 publications with IRF3 and Kidney Diseases
 Carcinoma Antibodies  >18 publications with IRF3 and Carcinoma
 Atherosclerosis Antibodies  >16 publications with IRF3 and Atherosclerosis
 Neoplasms, Experimental Antibodies  >11 publications with IRF3 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >8 publications with IRF3 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >176 publications with IRF3 and Blood
 Liver Antibodies  >68 publications with IRF3 and Liver
 Bone Antibodies  >58 publications with IRF3 and Bone
 Kidney Antibodies  >51 publications with IRF3 and Kidney
 Lung Antibodies  >49 publications with IRF3 and Lung
 Brain Antibodies  >35 publications with IRF3 and Brain
 Skin Antibodies  >27 publications with IRF3 and Skin
 Spleen Antibodies  >26 publications with IRF3 and Spleen
 Muscle Antibodies  >20 publications with IRF3 and Muscle
 Heart Antibodies  >12 publications with IRF3 and Heart
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