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anti-IFNB1 antibody :: Interferon b Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS660214 anti-IFNB1 antibody
Unit / Price
1 mg  /  $465 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interferon b (IFNB1), Monoclonal Antibody

 Also Known As   

Monoclonal mouse anti-human recombinant interferon beta

 Product Gene Name   

anti-IFNB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147640
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 Clonality    Monoclonal
 Isotype    IgG1 for MAb BF3
IgG2a for MAbs BB4 and BD9
IgG2b for MAb BG6
 Clone Number    BB4, BD9, BF3, BG6
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 Specificity    MAbs BB4, BD9 and BG6 recognize non-glycosylated (expressed in E Coli) and glycosylated (expressed in CHO) recombinant human interferon beta antigens. MAb BF3 recognizes only non-glycosylated interferon beta. There is no cross-reactivity with human interferon alpha or human interferon gamma.
 Purity/Purification    Chromatography on protein G Sepharose
 Form/Format    PBS, pH 7.4, 0.1 % sodium azide (NaN3)
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 Clone Note    Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with human recombinant full-size interferon beta, expressed in E Coli.
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 Preparation and Storage    4 degree C
 Other Notes    Small volumes of anti-IFNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IFNB1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-IFNB1 antibody    Antibodies are working in ELISA and Western blotting.
MAbs BB4 and BF3 can be used for coating and MAbs BD9 and BG6 can be used as conjugates in sandwich ELISA.
MAbs BD9 and BG6 have neutralizing activity in Western blotting.
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NCBI/Uniprot data below describe general gene information for IFNB1. It may not necessarily be applicable to this product.
 NCBI GI #    4504603
 NCBI GeneID    3456
 NCBI Accession #    NP_002167.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002176.2 [Other Products]
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 UniProt Secondary Accession #    Q5VWC9 [Other Products]
 UniProt Related Accession #    P01574 [Other Products]
 Molecular Weight    22,294 Da [Similar Products]
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 NCBI Official Full Name    interferon beta
 NCBI Official Synonym Full Names    interferon, beta 1, fibroblast
 NCBI Official Symbol    IFNB1 [Similar Products]
 NCBI Official Synonym Symbols   
IFB; IFF; IFNB
[Similar Products]
 NCBI Protein Information    interferon beta; IFN-beta; fibroblast interferon
 UniProt Protein Name    Interferon beta
 UniProt Synonym Protein Names   
Fibroblast interferon
 Protein Family    Interferon
 UniProt Gene Name    IFNB1 [Similar Products]
 UniProt Synonym Gene Names    IFB; IFNB; IFN-beta [Similar Products]
 UniProt Entry Name    IFNB_HUMAN
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 UniProt Comments for IFNB1    IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: extracellular space; extracellular region

Molecular Function: interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; response to virus; regulation of MHC class I biosynthetic process; natural killer cell activation; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; cell surface receptor linked signal transduction; negative regulation of viral genome replication; B cell differentiation; positive regulation of innate immune response; defense response to bacterium; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; defense response to virus; B cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein
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 Research Articles on IFNB1    1. A20 has a novel atheroprotective function in vascular cells through modulation of IFNgamma/STAT1 signaling in an IFNbeta-dependent, but NF-kappaB-independent, manner
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IFNB1 antibodyPathways associated with anti-IFNB1 antibody
 Reference Product  PubMed Publications
 IRF3 antibody  >18 publications with IFNB1 and IRF3
 IFNAR1 antibody  >6 publications with IFNB1 and IFNAR1
 IRF7 antibody  >4 publications with IFNB1 and IRF7
 STAT2 antibody  >3 publications with IFNB1 and STAT2
 EP300 antibody  >1 publications with IFNB1 and EP300
 CREBBP antibody  >1 publications with IFNB1 and CREBBP
 IRF1 antibody  >1 publications with IFNB1 and IRF1
 IFNAR2 antibody  >1 publications with IFNB1 and IFNAR2
 Products by Pathway  Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
Diseases associated with anti-IFNB1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with IFNB1 and Inflammation
 Immune System Diseases Antibodies  >8 publications with IFNB1 and Immune System Diseases
 Necrosis Antibodies  >7 publications with IFNB1 and Necrosis
 Carcinoma Antibodies  >4 publications with IFNB1 and Carcinoma
 Melanoma Antibodies  >3 publications with IFNB1 and Melanoma
 Leukemia Antibodies  >3 publications with IFNB1 and Leukemia
 Lung Neoplasms Antibodies  >3 publications with IFNB1 and Lung Neoplasms
 Heart Diseases Antibodies  >2 publications with IFNB1 and Heart Diseases
 Multiple Sclerosis Antibodies  >2 publications with IFNB1 and Multiple Sclerosis
 Pancreatic Neoplasms Antibodies  >2 publications with IFNB1 and Pancreatic Neoplasms
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