NP_443104.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interleukin-17F
NCBI Official Synonym Full Names
interleukin 17F
NCBI Protein Information
interleukin-17F; IL-24; cytokine ML-1; mutant IL-17F; interleukin-24; OTTHUMP00000016602
UniProt Protein Name
Interleukin-17F
UniProt Synonym Protein Names
Cytokine ML-1; Interleukin-24
UniProt Synonym Gene Names
UniProt Entry Name
IL17F_HUMAN
NCBI Summary for IL17F
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq]
UniProt Comments for IL17F
IL17F: Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Belongs to the IL-17 family.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: extracellular space; extracellular region
Molecular Function: protein homodimerization activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine binding; cytokine activity
Biological Process: proteoglycan metabolic process; negative regulation of angiogenesis; regulation of interleukin-8 biosynthetic process; regulation of transforming growth factor beta receptor signaling pathway; regulation of interleukin-2 biosynthetic process; cytokine biosynthetic process; regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; cartilage development; lymphotoxin A biosynthetic process; regulation of interleukin-6 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; inflammatory response
Disease: Candidiasis, Familial, 6
Research Articles on IL17F
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Pathways associated with anti-IL17F antibody
Diseases associated with anti-IL17F antibody
Organs/Tissues associated with anti-IL17F antibody
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