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anti-IL-6 antibody :: Mouse anti-Human Interleukin-6 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS550031 anti-IL-6 antibody
Unit / Price
0.5 mg  /  $550 +1 FREE 8GB USB
1 mg  /  $855 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-6 (IL-6), Monoclonal Antibody

 Also Known As   

Monoclonal Mouse Anti Human Interleukin-6

 Product Synonym Names    il-6; il6; interleukin-6; B-cell stimulatory factor; bsf; monoclonal; mab
 Product Gene Name   

anti-IL-6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147620
 3D Structure    ModBase 3D Structure for P05231
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    SB9H6
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    The IgG fraction of the tissue culture supernatant was purified by Protein A affinity chromatography.
 Form/Format    Prepared from sterile filtered solution at a concentration of 1mg/ml in PBS with 5% trehalose.
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 Host Note    This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with recombinant E. coli-derived Human IL-6.
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 Preparation and Storage    The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-IL-6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL-6 antibody

   IL6 is produced by many different cell types. The main sources in vivo are stimulated monocytes, fibroblasts, and endothelial cells. Macrophages, T-cells and B-lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells, and keratinocytes also produce IL6 after stimulation. IL6 is a member of a family of cytokines, which also includes LIF, CNTF, Oncostatin M, IL11, and CT- 1. All known members of the IL6 cytokine family induce hepatic expression of acute phase proteins. The IL6 receptor is expressed on T-cells, mitogen-activated B-cells, peripheral monocytes and some macrophage- and B-cell derived tumor cell types. It is not expressed in resting B-cells but in resting T- cells. The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids. It has been designated CD126.
 Product Categories/Family for anti-IL-6 antibody    Monoclonal
 Application Notes for anti-IL-6 antibody    Direct ELISA: This antibody can be used at 0.5-1ug/mLwith the appropriate secondary reagents to detect human Interleukin-6. The detection limit for human IL-6 is approximately 2ng/well.
Western blot: This monoclonal antibody has been tested in WB analysis of human IL-6. A suitable range of concentrations of this antibody for WB detection is 0.5-2 ug/ml.
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NCBI/Uniprot data below describe general gene information for IL-6. It may not necessarily be applicable to this product.
 NCBI GI #    186352
 NCBI GeneID    3569
 NCBI Accession #    AAC41704 [Other Products]
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 UniProt Primary Accession #    P05231 [Other Products]
 UniProt Secondary Accession #    Q9UCU2; Q9UCU3; Q9UCU4 [Other Products]
 UniProt Related Accession #    P05231; Q75MH2; Q8N6X1 [Other Products]
 Molecular Weight    23,718 Da
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 NCBI Official Full Name    interleukin 6
 UniProt Protein Name    Interleukin-6
 UniProt Synonym Protein Names   
B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2
 Protein Family    Interleukin
 UniProt Gene Name    IL6 [Similar Products]
 UniProt Synonym Gene Names    IFNB2; IL-6; BSF-2; CDF; IFN-beta-2 [Similar Products]
 UniProt Entry Name    IL6_HUMAN
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 NCBI Summary for IL-6    This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]
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 UniProt Comments for IL-6    IL6: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ). An inflammatory articular disorder with systemic- onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. Belongs to the IL-6 superfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p21

Cellular Component: extracellular space; cytoplasm; extracellular region; interleukin-6 receptor complex; external side of plasma membrane

Molecular Function: protein binding; interleukin-6 receptor binding; growth factor activity; cytokine activity

Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of collagen biosynthetic process; negative regulation of cytokine secretion; response to glucocorticoid stimulus; positive regulation of JAK-STAT cascade; positive regulation of leukocyte chemotaxis; glucose homeostasis; bone remodeling; positive regulation of tyrosine phosphorylation of Stat3 protein; response to caffeine; activation of NF-kappaB transcription factor; response to antibiotic; muscle maintenance; regulation of cell shape; monocyte chemotaxis; positive regulation of T-helper 2 cell differentiation; positive regulation of acute inflammatory response; negative regulation of gluconeogenesis; acute-phase response; positive regulation of T cell proliferation; response to electrical stimulus; cell growth; defense response to virus; neurite development; response to drug; platelet activation; positive regulation of protein import into nucleus, translocation; positive regulation of interleukin-6 production; negative regulation of fat cell differentiation; response to amino acid stimulus; defense response to protozoan; positive regulation of chemokine production; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; response to heat; cell redox homeostasis; positive regulation of B cell activation; negative regulation of protein kinase activity; neutrophil apoptosis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; response to calcium ion; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of muscle development; positive regulation of translation; negative regulation of hormone secretion; positive regulation of smooth muscle cell proliferation; neutrophil mediated immunity; regulation of circadian sleep/wake cycle, non-REM sleep; negative regulation of caspase activity; defense response to Gram-negative bacterium; response to insulin stimulus; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; response to peptidoglycan; positive regulation of cell proliferation; hepatic immune response; inflammatory response; aging; negative regulation of chemokine biosynthetic process; response to nutrient levels; cytokine and chemokine mediated signaling pathway; positive regulation of immunoglobulin secretion; regulation of angiogenesis; endocrine pancreas development; positive regulation of peptidyl-serine phosphorylation; humoral immune response; positive regulation of protein kinase B signaling cascade; positive regulation of osteoblast differentiation; response to cold; positive regulation of neuron differentiation; positive regulation of DNA replication; positive regulation of transmission of nerve impulse

Disease: Rheumatoid Arthritis, Systemic Juvenile; Arteriovenous Malformations Of The Brain; Kaposi Sarcoma, Susceptibility To; Inflammatory Bowel Disease 1
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Product References and Citations for anti-IL-6 antibody

   IL-6 protects against hyperoxia-induced mitochondrial damage via bcl-2–induced bak interactions with mitofusions .Am. J. Respir. Cell Mol. Biol., Oct 2009; 41: 385 - 396.
long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the stream study) : evidence of safety and efficacy in a 5-year extension study .Ann Rheum Dis, Oct 2009; 68: 1580 - 1584.
the second bovine β-galactoside-2,6-sialyltransferase (st6gal ii) : genomic organization and stimulation of its in vitro expression by IL-6 in bovine mammary epithelial cells .Glycobiology, Oct 2009; 19: 1082 - 1093.
IL-6 -174g/c promoter polymorphism in acute appendicitis .Lab Med, Oct 2009; 40: 600 - 603.
cell surface-bound il-1 is an upstream regulator of the senescence-associated IL-6/il-8 cytokine network .PNAS, Sep 2009; 10.1073/pnas.0905299106.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL-6 antibodyPathways associated with anti-IL-6 antibody
 Reference Product  PubMed Publications
 IL6R antibody  >58 publications with IL-6 and IL6R
 IL6ST antibody  >30 publications with IL-6 and IL6ST
 PTHLH antibody  >2 publications with IL-6 and PTHLH
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
Diseases associated with anti-IL-6 antibodyOrgans/Tissues associated with anti-IL-6 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1069 publications with IL-6 and Inflammation
 Neoplasms Antibodies  >539 publications with IL-6 and Neoplasms
 Cardiovascular Diseases Antibodies  >454 publications with IL-6 and Cardiovascular Diseases
 Lung Diseases Antibodies  >177 publications with IL-6 and Lung Diseases
 Leukemia Antibodies  >133 publications with IL-6 and Leukemia
 Atherosclerosis Antibodies  >126 publications with IL-6 and Atherosclerosis
 Liver Diseases Antibodies  >123 publications with IL-6 and Liver Diseases
 Obesity Antibodies  >122 publications with IL-6 and Obesity
 Insulin Resistance Antibodies  >101 publications with IL-6 and Insulin Resistance
 Kidney Diseases Antibodies  >98 publications with IL-6 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1570 publications with IL-6 and Blood
 Vascular Antibodies  >333 publications with IL-6 and Vascular
 Bone Antibodies  >218 publications with IL-6 and Bone
 Lung Antibodies  >205 publications with IL-6 and Lung
 Brain Antibodies  >192 publications with IL-6 and Brain
 Kidney Antibodies  >148 publications with IL-6 and Kidney
 Muscle Antibodies  >135 publications with IL-6 and Muscle
 Skin Antibodies  >98 publications with IL-6 and Skin
 Connective Tissue Antibodies  >95 publications with IL-6 and Connective Tissue
 Intestine Antibodies  >67 publications with IL-6 and Intestine
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