NP_032352.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
immunity-related GTPase family M protein 1
NCBI Official Synonym Full Names
immunity-related GTPase family M member 1
NCBI Official Synonym Symbols
Ifi1; Irgm; Iigp3; Iipg3; Ifggd3; LRG-47 [Similar Products]
NCBI Protein Information
immunity-related GTPase family M protein 1
UniProt Protein Name
Immunity-related GTPase family M protein 1
UniProt Synonym Protein Names
Interferon-inducible GTPase 3; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47; LRG-47
UniProt Synonym Gene Names
UniProt Entry Name
IRGM1_MOUSE
UniProt Comments for Irgm1
IRGM: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility. Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19). A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the interferon-inducible GTPase family.
Protein type: EC 3.6.5.-; Endoplasmic reticulum; Hydrolase
Cellular Component: Golgi apparatus; cell projection; membrane; lysosome; endoplasmic reticulum; late endosome; plasma membrane; cytoplasmic vesicle; endosome
Molecular Function: GTP binding; hydrolase activity; nucleotide binding
Biological Process: immune system process; innate immune response; autophagy; defense response
Product References and Citations for anti-Irgm1 antibody
Dhar, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107(27):12275-12280(2010) Xu, H., et al. FASEB J. 24(5):1583-1592(2010) Henry, S.C., et al. J. Leukoc. Biol. 87(2):333-343(2010) Zhao, Y.O., et al. PLoS ONE 5 (1), E8648 (2010) : Tiwari, S., et al. Nat. Immunol. 10(8):907-917(2009)
Research Articles on Irgm1
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Products associated with anti-Irgm1 antibody
Pathways associated with anti-Irgm1 antibody
Diseases associated with anti-Irgm1 antibody
Organs/Tissues associated with anti-Irgm1 antibody
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