View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-JAG1 antibody :: Mouse anti-Human JAG1 Monoclonal Antibody Catalog # MBS605931 Unit / Price 0.1 mL / $660 +1 FREE 8GB USB 5x0.1 mL / $2,800 +3 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name JAG1, Monoclonal Antibody Full Product Name JAG1 (Jagged1 AGS, AHD, AWS, HJ1, JAGL1, Alagille syndrome protein, hJ1, CD339 antigen, JAGL1) Product Synonym Names Anti -JAG1 (Jagged1 AGS, AHD, AWS, HJ1, JAGL1, Alagille syndrome protein, hJ1, CD339 antigen, JAGL1) Product Gene Name anti-JAG1 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Chromosome Location Chromosome: 20; NC_000020.10 (10618332..10654694, complement). Location: 20p12.1-p11.23 OMIM 118450 3D Structure ModBase 3D Structure for P78504 Clonality Monoclonal Isotype IgG Clone Number 9G373 Host Mouse Species Reactivity Human Specificity Recognizes human JAG1. Purity/Purification AscitesAscites Form/Format Supplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O. Immunogen Partial recombinant corresponding to aa531-621 of human JAG1 with a GST tag. Preparation and Storage Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Other Notes Small volumes of anti-JAG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-JAG1 antibody The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for multiple Notch receptors involved in the mediation of Notch signalling. It may be involved in cell-fate decision during hematopoiesis and seems to be involved in early and late stages of mammalian cardiovascular development. JAG1 is a trans membrane protein that is widely expressed in adult and fetal tissues. Mutations that alter the jagged 1 protein cause Alagille syndrome which is an autosomal dominant multisysstem disorder. Defects in JAG1 are also the cause of tetralogy of Fallot (TOF) which is a congenital heart anomaly. Product Categories/Family for anti-JAG1 antibody Antibodies; Abs to Notch Proteins Applications Tested/Suitable for anti-JAG1 antibody ELISA (EL/EIA), Western Blot (WB) Application Notes for anti-JAG1 antibody Suitable for use in ELISA and Western Blot. Testing Data of anti-JAG1 antibody MBS605931 detects a band of 35kD when used for WB detection against the antigen (partial recombinant human JAG1 with the GST tag). Note the GST tag alone has a molecular weight of 26KD. TOP NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product. NCBI GI # 2228793 NCBI GeneID 182 UniProt Primary Accession # P78504 [Other Products] UniProt Secondary Accession # O14902; O15122; Q15816; A0AV43[Other Products] UniProt Related Accession # P78504; Q4KMR2; Q99740[Other Products] TOP NCBI Official Full Name Jagged1 NCBI Official Synonym Full Names jagged 1 NCBI Official Symbol JAG1 [Similar Products] NCBI Official Synonym Symbols AGS; AHD; AWS; HJ1; CD339; JAGL1; MGC104644 [Similar Products] NCBI Protein Information protein jagged-1; OTTHUMP00000030278 UniProt Protein Name Protein jagged-1 Protein Family Protein jagged UniProt Entry Name JAG1_HUMAN TOP NCBI Summary for JAG1 The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq] TOP UniProt Comments for JAG1 JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p12.1-p11.23Cellular Component: membrane; integral to plasma membrane; apical part of cell; plasma membrane; extracellular regionMolecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding; structural molecule activityBiological Process: nervous system development; endothelial cell differentiation; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; keratinocyte differentiation; myoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; angiogenesis; positive regulation of Notch signaling pathwayDisease: Tetralogy Of Fallot; Alagille Syndrome 1 Research Articles on JAG1 1. the interaction between the PDZ domain of afadin (AF6_PDZ) and a series of polypeptides comprising the PDZ-binding motif, was studied. 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TOP Products associated with anti-JAG1 antibody Reference Product PubMed Publications NOTCH1 antibody >39 publications with JAG1 and NOTCH1 NOTCH2 antibody >24 publications with JAG1 and NOTCH2 NOTCH3 antibody >14 publications with JAG1 and NOTCH3 MFNG antibody >3 publications with JAG1 and MFNG JUN antibody >1 publications with JAG1 and JUN FOS antibody >1 publications with JAG1 and FOS Pathways associated with anti-JAG1 antibody Products by Pathway Pathway Diagram Delta-Notch Signaling Pathway antibodies Delta-Notch Signaling Pathway Diagram Notch Receptor Binds With A Ligand Pathway antibodies Notch Receptor Binds With A Ligand Pathway Diagram Notch Signaling Pathway antibodies Notch Signaling Pathway Diagram Notch Signaling Pathway antibodies Notch Signaling Pathway Diagram Notch Signaling Pathway antibodies Notch Signaling Pathway Diagram Receptor-ligand Binding Initiates The Second Proteolytic Cleavage Of Notch Receptor Pathway antibodies Receptor-ligand Binding Initiates The Second Proteolytic Cleavage Of Notch Receptor Pathway Diagram Signaling By Notch Pathway antibodies Signaling By Notch Pathway Diagram Diseases associated with anti-JAG1 antibody Disease Name Pubmed Publications Alagille Syndrome Antibodies >101 publications with JAG1 and Alagille Syndrome Congenital Abnormalities Antibodies >97 publications with JAG1 and Congenital Abnormalities Cardiovascular Diseases Antibodies >95 publications with JAG1 and Cardiovascular Diseases Heart Defects, Congenital Antibodies >93 publications with JAG1 and Heart Defects, Congenital Cholestasis Antibodies >87 publications with JAG1 and Cholestasis Neoplasms Antibodies >31 publications with JAG1 and Neoplasms Heart Diseases Antibodies >21 publications with JAG1 and Heart Diseases Chromosome Aberrations Antibodies >14 publications with JAG1 and Chromosome Aberrations Eye Abnormalities Antibodies >13 publications with JAG1 and Eye Abnormalities Tetralogy of Fallot Antibodies >12 publications with JAG1 and Tetralogy of Fallot Organs/Tissues associated with anti-JAG1 antibody Organ/Tissue Name Pubmed Publications Liver Antibodies >57 publications with JAG1 and Liver Heart Antibodies >41 publications with JAG1 and Heart Vascular Antibodies >29 publications with JAG1 and Vascular Eye Antibodies >25 publications with JAG1 and Eye Blood Antibodies >25 publications with JAG1 and Blood Embryonic Tissue Antibodies >20 publications with JAG1 and Embryonic Tissue Ear Antibodies >19 publications with JAG1 and Ear Kidney Antibodies >15 publications with JAG1 and Kidney Brain Antibodies >13 publications with JAG1 and Brain Muscle Antibodies >10 publications with JAG1 and Muscle TOP © 2006-24 MyBioSource.com. 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