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anti-JAGGED2 antibody :: Hamster JAGGED2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS219866
Unit / Price
0.1 mg  /  $210 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JAGGED2, Monoclonal Antibody

 Also Known As   

HAMSTER ANTI MOUSE JAGGED2

 Product Gene Name   

anti-JAGGED2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602570
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    HMJ2-1
 Host    Hamster
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    Jagged2-expressing CHO cells.
Histology Positive Control Tissue
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-JAGGED2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-JAGGED2 antibody

   Hamster anti Mouse JAGGED2 antibody, clone HMJ2-1 specifically recognizes Jagged2, one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta-like protein 1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Jagged2 is expressed by stromal and thymic lymphoid cells, and by splenic macrophages and dendritic cells (DCs), and plays a vital role during limb, craniofacial, tooth, and thymic development, as well as being implicated in the maintenance and function of neuronal cells in both the central (CNS) and enteric (gastrointestinal) nervous system. Studies have shown that the anti-tumor cytolytic activity of natural killer (NK) cells can be enhanced by Jagged2 stimulation, and that the vital role which DC Jagged2 expression plays in DC-mediated NK cell activation, may
 Applications Tested/Suitable for anti-JAGGED2 antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS)

 Application Notes for anti-JAGGED2 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
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 Testing Data of anti-JAGGED2 antibody    Paraffin embedded human testis stained with Hamster anti Mouse Jagged 2 (MBS219865) followed by Goat anti Hamster IgG:HRP (MBS235197)
anti-JAGGED2 antibody Testing Data image
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 Testing Data of anti-JAGGED2 antibody    Mouse Jagged 2 transfected cells stained with Hamster anti Mouse Jagged 2 (MBS219865)
anti-JAGGED2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for JAGGED2. It may not necessarily be applicable to this product.
 NCBI GI #    21704277
 NCBI GeneID    3714
 NCBI Accession #    NP_002217.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002226.4 [Other Products]
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 UniProt Secondary Accession #    Q9UE17; Q9UE99; Q9UNK8; Q9Y6P9; Q9Y6Q0 [Other Products]
 UniProt Related Accession #    Q9Y219 [Other Products]
 Molecular Weight    129,235 Da
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 NCBI Official Full Name    protein jagged-2 isoform a
 NCBI Official Synonym Full Names    jagged 2
 NCBI Official Symbol    JAG2 [Similar Products]
 NCBI Official Synonym Symbols   
HJ2; SER2
[Similar Products]
 NCBI Protein Information    protein jagged-2
 UniProt Protein Name    Protein jagged-2
 UniProt Gene Name    JAG2 [Similar Products]
 UniProt Synonym Gene Names    Jagged2; hJ2 [Similar Products]
 UniProt Entry Name    JAG2_HUMAN
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 NCBI Summary for JAGGED2    The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for JAGGED2    JAG2: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development. Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding

Biological Process: regulation of cell adhesion; thymic T cell selection; Notch signaling pathway; in utero embryonic development; Notch receptor processing; cell cycle; regulation of cell migration; odontogenesis of dentine-containing teeth; regulation of cell proliferation; respiratory system process; morphogenesis of embryonic epithelium; spermatogenesis; auditory receptor cell fate commitment; cell differentiation; skeletal development; T cell differentiation; gamma-delta T cell differentiation
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 Research Articles on JAGGED2    1. Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-JAGGED2 antibodyPathways associated with anti-JAGGED2 antibody
 Reference Product  PubMed Publications
 NOTCH1 antibody  >86 publications with JAGGED2 and NOTCH1
 NOTCH2 antibody  >31 publications with JAGGED2 and NOTCH2
 NOTCH3 antibody  >27 publications with JAGGED2 and NOTCH3
 DLL4 antibody  >20 publications with JAGGED2 and DLL4
 DLL1 antibody  >19 publications with JAGGED2 and DLL1
 HES5 antibody  >12 publications with JAGGED2 and HES5
 MIB1 antibody  >1 publications with JAGGED2 and MIB1
 ADAM10 antibody  >1 publications with JAGGED2 and ADAM10
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
Diseases associated with anti-JAGGED2 antibodyOrgans/Tissues associated with anti-JAGGED2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >13 publications with JAGGED2 and Cardiovascular Diseases
 Craniofacial Abnormalities Antibodies  >10 publications with JAGGED2 and Craniofacial Abnormalities
 Nervous System Diseases Antibodies  >8 publications with JAGGED2 and Nervous System Diseases
 Breast Neoplasms Antibodies  >7 publications with JAGGED2 and Breast Neoplasms
 Inflammation Antibodies  >6 publications with JAGGED2 and Inflammation
 Chromosome Aberrations Antibodies  >5 publications with JAGGED2 and Chromosome Aberrations
 Lung Neoplasms Antibodies  >5 publications with JAGGED2 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with JAGGED2 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >5 publications with JAGGED2 and Cell Transformation, Neoplastic
 Pancreatic Neoplasms Antibodies  >4 publications with JAGGED2 and Pancreatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with JAGGED2 and Blood
 Bone Antibodies  >24 publications with JAGGED2 and Bone
 Brain Antibodies  >20 publications with JAGGED2 and Brain
 Vascular Antibodies  >16 publications with JAGGED2 and Vascular
 Lung Antibodies  >11 publications with JAGGED2 and Lung
 Heart Antibodies  >8 publications with JAGGED2 and Heart
 Skin Antibodies  >7 publications with JAGGED2 and Skin
 Nerve Antibodies  >6 publications with JAGGED2 and Nerve
 Intestine Antibodies  >5 publications with JAGGED2 and Intestine
 Placenta Antibodies  >3 publications with JAGGED2 and Placenta
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