NP_001307852.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
133,277 Da
NCBI Official Full Name
tyrosine-protein kinase JAK1 isoform 1
NCBI Official Synonym Full Names
Janus kinase 1
NCBI Protein Information
tyrosine-protein kinase JAK1
UniProt Protein Name
Tyrosine-protein kinase JAK1
UniProt Synonym Protein Names
Janus kinase 1; JAK-1
UniProt Synonym Gene Names
NCBI Summary for JAK1
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Comments for JAK1
JAK1: a widely expressed non-receptor tyrosine-kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Couples cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. A selective Jak1 inhibitor induces apoptosis in NRP-154 prostate cancer cell line. A single mutation seen in tyrosine kinome screen of colon cancers. Activated in B cell lines from patients with post-transplant lymphoproliferative disorder, and in a mouse Lck-driven T cell lymphoma. Inhibitor: Piceatannol.
Protein type: EC 2.7.10.2; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: cytoplasm; cytoskeleton; cytosol; endosome; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; nucleus
Molecular Function: ATP binding; CCR5 chemokine receptor binding; growth hormone receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding; ubiquitin protein ligase binding
Biological Process: cell differentiation; cell migration; innate immune response; interleukin-2-mediated signaling pathway; interleukin-7-mediated signaling pathway; interleukin-9-mediated signaling pathway; MAPK cascade; peptidyl-tyrosine autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of molecular function; response to antibiotic; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on JAK1
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Products associated with anti-JAK1 antibody
Pathways associated with anti-JAK1 antibody
Diseases associated with anti-JAK1 antibody
Organs/Tissues associated with anti-JAK1 antibody
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