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anti-jak1 antibody :: Mouse anti-Human, Mouse JAK1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS608588 anti-jak1 antibody
Unit / Price
0.1 mg  /  $630 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JAK1, Monoclonal Antibody

 Also Known As   

JAK1 (Janus Kinase 1)

 Product Synonym Names    Anti -JAK1 (Janus Kinase 1)
 Product Gene Name   

anti-jak1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_007117.5 (31060241..31118556)
 3D Structure    ModBase 3D Structure for O12990
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    10F612
 Host    Mouse
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes endogenous human Jak1 at ~100-120kD.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a lyophilized powder from PBS, ph 7.4, 5% trehalose. Reconstitute with 200ul of sterile PBS.
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 Immunogen    Recombinant protein corresponding to aa32-286 of human Jak1 expressed in E. coli (P23458).
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-jak1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-jak1 antibody

   Janus Kinase 1 (Jak1) belongs to a family of protein tyrosine kinases that couple to cytokine receptors and are activated by ligand binding to these receptors. Activation of Jak1 occurs via phosphorylation at two adjacent tyrosine residues, Y1022 and Y1023, within the kinase domain. Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites. Jak1 is required for the activation of STAT1 and STAT2 in response to IFN-alpha.
 Product Categories/Family for anti-jak1 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-jak1 antibody   

Western Blot (WB)

 Application Notes for anti-jak1 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 1ug/ml detects JAK1 on NIH-3T3 mouse embryonic fibroblast cell line, Daudi human Burkitt's lymphoma cell line, HeLa human cervical epithelial carcinoma cell line and LNCaP human prostate cancer cell line.
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NCBI/Uniprot data below describe general gene information for jak1. It may not necessarily be applicable to this product.
 NCBI GI #    226237498
 NCBI GeneID    30280
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 UniProt Primary Accession #    O12990 [Other Products]
 UniProt Secondary Accession #    O73880 [Other Products]
 UniProt Related Accession #    O12990; Q7ZU16 [Other Products]
 Molecular Weight    132,481 Da [Similar Products]
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 NCBI Official Full Name    jak1
 NCBI Official Synonym Full Names    Janus kinase 1
 NCBI Official Symbol    jak1 [Similar Products]
 NCBI Official Synonym Symbols   
jak1
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase JAK1; jak-1; jak1 kinase; etID309794.6
 UniProt Protein Name    Tyrosine-protein kinase JAK1
 UniProt Synonym Protein Names   
Janus kinase 1
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    jak1 [Similar Products]
 UniProt Entry Name    JAK1_DANRE
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 UniProt Comments for jak1    Function: Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. Ref.1

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location: Endomembrane system; Peripheral membrane protein

By similarity. Note: Wholly intracellular, possibly membrane associated

Developmental stage: Present in the unfertilized egg through to the blastula stage where it is distributed uniformly. Levels drop rapidly at four hours development, remain very low until 10 hours, then gradually increase from 12 hours with a rapid increase at 48 hours. At 48 hours it is concentrated in the region of the gill arches. Also present in the adult. Ref.1

Domain: Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1.

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.Contains 1 FERM domain.Contains 1 protein kinase domain.Contains 1 SH2 domain.
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 Research Articles on jak1    1. Required for cell migration of anterior mesendoderm during gastrulation, resulting in extension of the anterior body axis. MO/dominant negative expression gives identical morphotype/phenotype to STAT3alpha knockdown.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-jak1 antibodyOrgans/Tissues associated with anti-jak1 antibody
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 IL-2 Signaling Pathway antibodies  IL-2 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >65 publications with jak1 and Brain
 Muscle Antibodies  >62 publications with jak1 and Muscle
 Heart Antibodies  >53 publications with jak1 and Heart
 Kidney Antibodies  >25 publications with jak1 and Kidney
 Eye Antibodies  >9 publications with jak1 and Eye
 Reproductive System Antibodies  >5 publications with jak1 and Reproductive System
 Whole Body Antibodies  >1 publications with jak1 and Whole Body
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