AAC50950.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,279 Da
NCBI Official Full Name
JAK3
NCBI Official Synonym Full Names
Janus kinase 3
NCBI Official Synonym Symbols
JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN [Similar Products]
NCBI Protein Information
tyrosine-protein kinase JAK3
UniProt Protein Name
Tyrosine-protein kinase JAK3
UniProt Synonym Protein Names
Janus kinase 3; JAK-3; Leukocyte janus kinase; L-JAK
UniProt Synonym Gene Names
NCBI Summary for JAK3
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
UniProt Comments for JAK3
JAK3: a non-receptor tyrosine-kinase of the Jak family expressed predominantly in immune cells. Mediates signal transduction via the common gamma-chain of cytokine receptors, including IL-2, -4, -7, -9, and -15. Interacts with members of the STAT (signal transduction and activators of transcription) family. Interacts with STAM2 and SHB. Contains two protein kinase domains. Mutations that abrogate JAK3 function cause an autosomal SCID (severe combined immunodeficiency disease). Inhibitor: R017s for organ transplants. Three differentially spliced isoforms have been described.
Protein type: EC 2.7.10.2; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: cytosol; extrinsic to internal side of plasma membrane
Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding
Biological Process: B cell differentiation; cell migration; enzyme linked receptor protein signaling pathway; innate immune response; MAPKKK cascade; negative regulation of dendritic cell cytokine production; negative regulation of FasL biosynthetic process; negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; negative regulation of T cell activation; negative regulation of T-helper 1 cell differentiation; peptidyl-tyrosine phosphorylation; positive regulation of T cell proliferation; protein amino acid phosphorylation; STAT protein nuclear translocation; T cell homeostasis; tyrosine phosphorylation of STAT protein
Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-negative
Research Articles on JAK3
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Products associated with anti-JAK3 antibody
Pathways associated with anti-JAK3 antibody
Diseases associated with anti-JAK3 antibody
Organs/Tissues associated with anti-JAK3 antibody
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