NP_000206.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 125 kDa Predicted: 126 kDa
NCBI Official Full Name
tyrosine-protein kinase JAK3
NCBI Official Synonym Full Names
Janus kinase 3
NCBI Official Synonym Symbols
JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN [Similar Products]
NCBI Protein Information
tyrosine-protein kinase JAK3
UniProt Protein Name
Tyrosine-protein kinase JAK3
UniProt Synonym Protein Names
Janus kinase 3; JAK-3; Leukocyte janus kinase; L-JAK
UniProt Synonym Gene Names
NCBI Summary for JAK3
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
UniProt Comments for JAK3
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Product References and Citations for anti-JAK3 antibody
Chen L, Zhou D, Liu Z, Huang X, Liu Q, Kang Y, Chen Z, Guo Y, Zhu H, Sun C; Journal: Oncol Rep. Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway.
Research Articles on JAK3
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Products associated with anti-JAK3 antibody
Pathways associated with anti-JAK3 antibody
Diseases associated with anti-JAK3 antibody
Organs/Tissues associated with anti-JAK3 antibody
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