NM_001348091.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,208 Da
NCBI Official Full Name
junctional adhesion molecule A isoform 6
NCBI Official Synonym Full Names
F11 receptor
NCBI Official Synonym Symbols
JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1 [Similar Products]
NCBI Protein Information
junctional adhesion molecule A
UniProt Protein Name
Junctional adhesion molecule A
UniProt Synonym Protein Names
Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD_antigen: CD321
UniProt Synonym Gene Names
UniProt Entry Name
JAM1_HUMAN
NCBI Summary for JAM-A/F11R
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
UniProt Comments for JAM-A/F11R
JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q21.2-q21.3
Cellular Component: cell junction; cell-cell adherens junction; intercellular junction; microtubule cytoskeleton; plasma membrane; tight junction
Molecular Function: PDZ domain binding; protein binding
Biological Process: actomyosin structure organization and biogenesis; extracellular matrix organization and biogenesis; inflammatory response; intestinal absorption; leukocyte migration; positive regulation of GTPase activity; transforming growth factor beta receptor signaling pathway
Research Articles on JAM-A/F11R
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Products associated with anti-JAM-A/F11R antibody
Pathways associated with anti-JAM-A/F11R antibody
Diseases associated with anti-JAM-A/F11R antibody
Organs/Tissues associated with anti-JAM-A/F11R antibody
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