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anti-JNK antibody :: Mouse anti-Human JNK Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS692393 anti-JNK antibody
Unit / Price
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JNK, Monoclonal Antibody

 Also Known As   

Mouse Anti-Human JNK

 Product Gene Name   

anti-JNK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M64174 mRNA
 3D Structure    ModBase 3D Structure for P23458
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    4M14
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Lyophilized
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 Reconstitution    Reconstitute the antibody with 500 ul sterile PBS and the final concentration is 200 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C.
Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-JNK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-JNK antibody

   This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells) from a mouse immunized with Recombinant human JNK.
 Applications Tested/Suitable for anti-JNK antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for JNK. It may not necessarily be applicable to this product.
 NCBI GI #    215274013
 NCBI GeneID    3716
 NCBI Accession #    P23458.2 [Other Products]
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 UniProt Primary Accession #    P23458 [Other Products]
 UniProt Secondary Accession #    Q59GQ2; Q9UD26 [Other Products]
 UniProt Related Accession #    P23458 [Other Products]
 Molecular Weight    133,277 Da
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 NCBI Official Full Name    Tyrosine-protein kinase JAK1
 NCBI Official Synonym Full Names    Janus kinase 1
 NCBI Official Symbol    JAK1 [Similar Products]
 NCBI Official Synonym Symbols   
JTK3; JAK1A; JAK1B
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase JAK1
 UniProt Protein Name    Tyrosine-protein kinase JAK1
 UniProt Synonym Protein Names   
Janus kinase 1; JAK-1
 Protein Family    JNK-interacting protein
 UniProt Gene Name    JAK1 [Similar Products]
 UniProt Synonym Gene Names    JAK1A; JAK1B; JAK-1 [Similar Products]
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 NCBI Summary for JNK    This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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 UniProt Comments for JNK    JAK1: a widely expressed non-receptor tyrosine-kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Couples cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. A selective Jak1 inhibitor induces apoptosis in NRP-154 prostate cancer cell line. A single mutation seen in tyrosine kinome screen of colon cancers. Activated in B cell lines from patients with post-transplant lymphoproliferative disorder, and in a mouse Lck-driven T cell lymphoma. Inhibitor: Piceatannol.

Protein type: EC 2.7.10.2; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; nucleus

Molecular Function: growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding; ubiquitin protein ligase binding

Biological Process: cell differentiation; cell migration; innate immune response; MAPKKK cascade; protein amino acid phosphorylation; regulation of cell proliferation; response to antibiotic; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on JNK    1. JAK1 rs310241 C-related genotype and allele are involved in AR susceptibility, making them potentially useful genetic biomarkers for allergic rhinitis susceptibility in the Chinese Han population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-JNK antibodyPathways associated with anti-JNK antibody
 Reference Product  PubMed Publications
 STAT3 antibody  >739 publications with JNK and STAT3
 STAT1 antibody  >668 publications with JNK and STAT1
 STAT2 antibody  >161 publications with JNK and STAT2
 STAT6 antibody  >145 publications with JNK and STAT6
 SOCS3 antibody  >75 publications with JNK and SOCS3
 STAT5B antibody  >45 publications with JNK and STAT5B
 STAT5A antibody  >41 publications with JNK and STAT5A
 PTPN11 antibody  >39 publications with JNK and PTPN11
 IRS1 antibody  >27 publications with JNK and IRS1
 IL2RB antibody  >7 publications with JNK and IL2RB
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 EGF/EGFR Signaling Pathway antibodies  EGF/EGFR Signaling Pathway Diagram
 EGFR Tyrosine Kinase Inhibitor Resistance Pathway antibodies  EGFR Tyrosine Kinase Inhibitor Resistance Pathway Diagram
Diseases associated with anti-JNK antibodyOrgans/Tissues associated with anti-JNK antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >206 publications with JNK and Inflammation
 Disease Models, Animal Antibodies  >107 publications with JNK and Disease Models, Animal
 Necrosis Antibodies  >102 publications with JNK and Necrosis
 Liver Diseases Antibodies  >83 publications with JNK and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >57 publications with JNK and Carcinoma, Hepatocellular
 Anemia Antibodies  >54 publications with JNK and Anemia
 Liver Neoplasms Antibodies  >54 publications with JNK and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >53 publications with JNK and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >51 publications with JNK and Fibrosis
 Neoplasms, Experimental Antibodies  >48 publications with JNK and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >545 publications with JNK and Blood
 Bone Antibodies  >143 publications with JNK and Bone
 Liver Antibodies  >135 publications with JNK and Liver
 Bone Marrow Antibodies  >113 publications with JNK and Bone Marrow
 Lung Antibodies  >103 publications with JNK and Lung
 Brain Antibodies  >101 publications with JNK and Brain
 Muscle Antibodies  >88 publications with JNK and Muscle
 Vascular Antibodies  >77 publications with JNK and Vascular
 Heart Antibodies  >74 publications with JNK and Heart
 Skin Antibodies  >61 publications with JNK and Skin
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