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anti-JAG1 antibody :: Rabbit anti-Human Jagged1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601514 anti-JAG1 antibody
Unit / Price
0.1 mL  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Jagged1 (JAG1), Monoclonal Antibody

 Also Known As   

Jagged1 (JAG1, AGS, AHD, AWS, HJ1, JAGL1, Alagille syndrome protein)

 Product Synonym Names    Anti -Jagged1 (JAG1, AGS, AHD, AWS, HJ1, JAGL1, Alagille syndrome protein)
 Product Gene Name   

anti-JAG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (10618332..10654694, complement). Location: 20p12.1-p11.23
 OMIM    118450
 3D Structure    ModBase 3D Structure for P78504
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    7H29
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Detects endogenous levels of total Jagged1 protein. Does not cross-react wtih Jagged2.
 Purity/Purification    Supernatant
Supernatant
 Form/Format    Supplied as a liquid in 10 mM sodium HEPES (pH 7.5), 150mM NaCl, 100ug/ml BSA, 50% glycerol and less than 0.02% sodium azide.
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 Immunogen    Synthetic peptide (KLH-coupled) corresponding to residues surrounding Gly867 (extracellular region) of human Jagged1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-JAG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-JAG1 antibody

   Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch (1,2). Five DSL proteins have been identified in mammals: Jagged1, Jagged2, delta-like 1 (Dll1), Dll3 and Dll4 (3). Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the gamma-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus where it activates transcription. Notch ligands may also be processed in a way similiar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions (4-6).
 Product Categories/Family for anti-JAG1 antibody    Antibodies; Abs to Notch Proteins
 Applications Tested/Suitable for anti-JAG1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-JAG1 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000
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NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product.
 NCBI GI #    2228793
 NCBI GeneID    182
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 UniProt Primary Accession #    P78504 [Other Products]
 UniProt Secondary Accession #    O14902; O15122; Q15816; A0AV43 [Other Products]
 UniProt Related Accession #    P78504; Q4KMR2; Q99740 [Other Products]
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 NCBI Official Full Name    Jagged1
 NCBI Official Synonym Full Names    jagged 1
 NCBI Official Symbol    JAG1 [Similar Products]
 NCBI Official Synonym Symbols   
AGS; AHD; AWS; HJ1; CD339; JAGL1; MGC104644
[Similar Products]
 NCBI Protein Information    protein jagged-1; OTTHUMP00000030278
 UniProt Protein Name    Protein jagged-1
 Protein Family    Protein jagged
 UniProt Entry Name    JAG1_HUMAN
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 NCBI Summary for JAG1    The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq]
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 UniProt Comments for JAG1    JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p12.1-p11.23

Cellular Component: membrane; integral to plasma membrane; apical part of cell; extracellular region; plasma membrane

Molecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding; structural molecule activity

Biological Process: endothelial cell differentiation; nervous system development; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; keratinocyte differentiation; myoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; angiogenesis; positive regulation of Notch signaling pathway

Disease: Tetralogy Of Fallot; Alagille Syndrome 1
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 Research Articles on JAG1    1. the interaction between the PDZ domain of afadin (AF6_PDZ) and a series of polypeptides comprising the PDZ-binding motif, was studied.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-JAG1 antibodyPathways associated with anti-JAG1 antibody
 Reference Product  PubMed Publications
 NOTCH1 antibody  >39 publications with JAG1 and NOTCH1
 NOTCH2 antibody  >24 publications with JAG1 and NOTCH2
 NOTCH3 antibody  >14 publications with JAG1 and NOTCH3
 MFNG antibody  >3 publications with JAG1 and MFNG
 JUN antibody  >1 publications with JAG1 and JUN
 FOS antibody  >1 publications with JAG1 and FOS
 Products by Pathway  Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Notch Receptor Binds With A Ligand Pathway antibodies  Notch Receptor Binds With A Ligand Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Receptor-ligand Binding Initiates The Second Proteolytic Cleavage Of Notch Receptor Pathway antibodies  Receptor-ligand Binding Initiates The Second Proteolytic Cleavage Of Notch Receptor Pathway Diagram
 Signaling By Notch Pathway antibodies  Signaling By Notch Pathway Diagram
Diseases associated with anti-JAG1 antibodyOrgans/Tissues associated with anti-JAG1 antibody
 Disease Name  Pubmed Publications
 Alagille Syndrome Antibodies  >101 publications with JAG1 and Alagille Syndrome
 Congenital Abnormalities Antibodies  >97 publications with JAG1 and Congenital Abnormalities
 Cardiovascular Diseases Antibodies  >95 publications with JAG1 and Cardiovascular Diseases
 Heart Defects, Congenital Antibodies  >93 publications with JAG1 and Heart Defects, Congenital
 Cholestasis Antibodies  >87 publications with JAG1 and Cholestasis
 Neoplasms Antibodies  >31 publications with JAG1 and Neoplasms
 Heart Diseases Antibodies  >21 publications with JAG1 and Heart Diseases
 Chromosome Aberrations Antibodies  >14 publications with JAG1 and Chromosome Aberrations
 Eye Abnormalities Antibodies  >13 publications with JAG1 and Eye Abnormalities
 Tetralogy of Fallot Antibodies  >12 publications with JAG1 and Tetralogy of Fallot
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >57 publications with JAG1 and Liver
 Heart Antibodies  >41 publications with JAG1 and Heart
 Vascular Antibodies  >29 publications with JAG1 and Vascular
 Eye Antibodies  >25 publications with JAG1 and Eye
 Blood Antibodies  >25 publications with JAG1 and Blood
 Embryonic Tissue Antibodies  >20 publications with JAG1 and Embryonic Tissue
 Ear Antibodies  >19 publications with JAG1 and Ear
 Kidney Antibodies  >15 publications with JAG1 and Kidney
 Brain Antibodies  >13 publications with JAG1 and Brain
 Muscle Antibodies  >10 publications with JAG1 and Muscle
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