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anti-JAM-B antibody :: Mouse anti-Human Junctional adhesion molecule B (JAM-B) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690583 anti-JAM-B antibody
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Junctional adhesion molecule B (JAM-B), Monoclonal Antibody

 Also Known As   

Mouse Anti-Human Junctional adhesion molecule B (JAM-B)

 Product Synonym Names    JAM2; JAMB; CD322; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43
 Product Gene Name   

anti-JAM-B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_000021.9 (25639282..25717562). Location: 21q21.2
 OMIM    606870
 3D Structure    ModBase 3D Structure for P57087
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    (4L28)
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of JAM-B (also called VE-JAM).
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-JAM-B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-JAM-B antibody

   Members of the junctional adhesion molecule (JAM) family are type I transmembrane glycoproteins of the immunoglobulin (Ig) superfamily that are localized in the tight junctions between endothelial or epithelial cells and appear to be involved in leukocyte transmigration. JAM-A, also known as platelet adhesion molecule 1 (PAM-1) and platelet F11 receptor, contains two V-type Ig-like domains, forms homodimers, and interacts with LFA-1. JAM-B (vasculo-endothelial or VE-JAM) and JAM-C each contain two Ig domains (one V-type and one C2-type), a cytoplasmic PDZ-binding motif and a PKC phosphorylation site. JAM-C interacts with MAC-1 and facilitates JAM-B interaction with integrin alpha 4 beta 1.
 Applications Tested/Suitable for anti-JAM-B antibody   

Western Blot (WB), Neutr

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NCBI/Uniprot data below describe general gene information for JAM-B. It may not necessarily be applicable to this product.
 NCBI GI #    393715111
 NCBI GeneID    58494
 NCBI Accession #    NP_001257336.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001270407.1 [Other Products]
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 UniProt Primary Accession #    P57087 [Other Products]
 UniProt Secondary Accession #    Q6UXG6; Q6YNC1; B2R6T9; B4DGT9 [Other Products]
 UniProt Related Accession #    P57087 [Other Products]
 Molecular Weight    33,207 Da
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 NCBI Official Full Name    junctional adhesion molecule B isoform 2
 NCBI Official Synonym Full Names    junctional adhesion molecule 2
 NCBI Official Symbol    JAM2 [Similar Products]
 NCBI Official Synonym Symbols   
JAMB; CD322; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43
[Similar Products]
 NCBI Protein Information    junctional adhesion molecule B; JAM-2; JAM-IT/VE-JAM; vascular endothelial junction-associated molecule
 UniProt Protein Name    Junctional adhesion molecule B
 UniProt Synonym Protein Names   
Junctional adhesion molecule 2; JAM-2; Vascular endothelial junction-associated molecule
 Protein Family    Junctional adhesion molecule
 UniProt Gene Name    JAM2 [Similar Products]
 UniProt Synonym Gene Names    C21orf43; VEJAM; JAM-B; JAM-2; VE-JAM [Similar Products]
 UniProt Entry Name    JAM2_HUMAN
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 NCBI Summary for JAM-B    This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
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 UniProt Comments for JAM-B    Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

Subunit structure: Interacts with JAM3. Ref.9

Subcellular location: Cell junction › tight junction

By similarity. Cell membrane; Single-pass type I membrane protein

By similarity. Note: Localized at tight junctions of both epithelial and endothelial cells

By similarity.

Tissue specificity: Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells. Ref.1

Sequence similarities: Belongs to the immunoglobulin superfamily.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.
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 Research Articles on JAM-B    1. These data brought new evidences for the role of JAM2 and JAM3 in progression of gastric adenocarcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-JAM-B antibodyPathways associated with anti-JAM-B antibody
 Reference Product  PubMed Publications
 JAM3 antibody  >22 publications with JAM-B and JAM3
 ITGA4 antibody  >1 publications with JAM-B and ITGA4
 TJP1 antibody  >1 publications with JAM-B and TJP1
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
Diseases associated with anti-JAM-B antibodyOrgans/Tissues associated with anti-JAM-B antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with JAM-B and Inflammation
 Carcinoma Antibodies  >4 publications with JAM-B and Carcinoma
 Neoplasm Metastasis Antibodies  >2 publications with JAM-B and Neoplasm Metastasis
 Neurobehavioral Manifestations Antibodies  >1 publications with JAM-B and Neurobehavioral Manifestations
 Prostatic Diseases Antibodies  >1 publications with JAM-B and Prostatic Diseases
 Congenital Abnormalities Antibodies  >1 publications with JAM-B and Congenital Abnormalities
 Adenocarcinoma Antibodies  >1 publications with JAM-B and Adenocarcinoma
 Breast Neoplasms Antibodies  >1 publications with JAM-B and Breast Neoplasms
 Necrosis Antibodies  >1 publications with JAM-B and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with JAM-B and Brain
 Embryonic Tissue Antibodies  >6 publications with JAM-B and Embryonic Tissue
 Lung Antibodies  >5 publications with JAM-B and Lung
 Eye Antibodies  >3 publications with JAM-B and Eye
 Testis Antibodies  >3 publications with JAM-B and Testis
 Kidney Antibodies  >3 publications with JAM-B and Kidney
 Nerve Antibodies  >3 publications with JAM-B and Nerve
 Ear Antibodies  >2 publications with JAM-B and Ear
 Tonsil Antibodies  >2 publications with JAM-B and Tonsil
 Bone Antibodies  >2 publications with JAM-B and Bone
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