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anti-CDH6 antibody :: Mouse anti-Human, Rat K-Cadherin/Cadherin-6 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS570155
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 Product Name   

K-Cadherin/Cadherin-6 (CDH6), Monoclonal Antibody

 Also Known As   

Mouse anti K-Cadherin/Cadherin-6

 Product Gene Name   

anti-CDH6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (31193796..31325237). Location: 5p13.3
 OMIM    603007
 3D Structure    ModBase 3D Structure for P55285
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2B6
 Host    Mouse
 Species Reactivity    Human, Rat
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 Specificity    2B6 recognizes the extracellular domain of cadherin-6.
 Form/Format    Each vial contains 1ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide.
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 Source Note    2B6 is a Mouse monoclonal IgG1 antibody obtained by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BABL/c Mouse immunized with affinity purified extracellular domain of Human cadherin-6-GST fusion protein.
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 Preparation and Storage    Store at 4 degree C, or in small aliquots at -20 degree C.
 Other Notes    Small volumes of anti-CDH6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDH6 antibody

   Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the Catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived.
 Product Categories/Family for anti-CDH6 antibody    Cell adhesion, Cell adhesion
 Applications Tested/Suitable for anti-CDH6 antibody   

Immunocytochemistry (IHC), Immunohistochemistry (IHC) (frozen), Immunohistochemistry (IHC) (paraffin), Western Blot (WB)

 Application Notes for anti-CDH6 antibody    2B6 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen sections when using a PBS buffer containing 0.1 mM CaCl2 and 0.1 mM MgCl2. 2B6 is also suitable for and immunohistochemistry on praraffin-embedded sections. Optimal antibody dilution should be determined by titRation; recommended range is 1:2 - 1:5 for immunohistochemistry with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent, and 1:2 - 1:25 for immunoblotting appliCations.
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 Testing Data of anti-CDH6 antibody    Figure 1: Immunohistochemistry on frozen section of human kidney: positive reactivity in renal tubules (epithelium)
anti-CDH6 antibody Testing Data image
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 Testing Data of anti-CDH6 antibody    Figure 2: Immunohistochemistry on paraffin section of human kidney
anti-CDH6 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CDH6. It may not necessarily be applicable to this product.
 NCBI GI #    4826673
 NCBI GeneID    1004
 NCBI Accession #    NP_004923.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004932.3 [Other Products]
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 UniProt Primary Accession #    P55285 [Other Products]
 UniProt Secondary Accession #    Q9BWS0; A8K5H5 [Other Products]
 UniProt Related Accession #    P55285 [Other Products]
 Molecular Weight    88,309 Da [Similar Products]
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 NCBI Official Full Name    cadherin-6 preproprotein
 NCBI Official Synonym Full Names    cadherin 6, type 2, K-cadherin (fetal kidney)
 NCBI Official Symbol    CDH6 [Similar Products]
 NCBI Official Synonym Symbols   
CAD6; KCAD; FLJ14176; DKFZp564N1116
[Similar Products]
 NCBI Protein Information    cadherin-6; OTTHUMP00000115839; OTTHUMP00000220908
 UniProt Protein Name    Cadherin-6
 UniProt Synonym Protein Names   
Kidney cadherin
 Protein Family    Cadherin
 UniProt Gene Name    CDH6 [Similar Products]
 UniProt Entry Name    CADH6_HUMAN
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 NCBI Summary for CDH6    This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq]
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 UniProt Comments for CDH6    CDH6: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 5p13.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: calcium ion binding

Biological Process: intercellular junction assembly and maintenance; homophilic cell adhesion; cell adhesion
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Product References and Citations for anti-CDH6 antibody

   Shimazui, T., Oosterwijk, E., Akaza, H., Bringuier, P., Ruijter, E., van Berkel, H., Wakka, J. O., van Bokhoven, A., Debruyne, F. M., and Schalken, J. A. (1998). Expression of cadherin-6 as a novel diagnostic tool to predict prognosis of patients with E-cadherin-absent renal cell carcinoma, Clin Cancer Res 4, 2419-24. Shimazui, T., Oosterwijk-Wakka, J., Akaza, H., Bringuier, P. P., Ruijter, E., Debruyne, F. M., Schalken, J. A., and Oosterwijk, E. (2000). AlteRations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma, Eur Urol 38, 331-8.
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 Research Articles on CDH6    1. The chromatin modifications were determined at five PRC2 targets commonly underexpressed in multiple myeloma (CIITA, CXCL12, GATA2, CDH6 and ICSBP/IRF8). The selected genes were confirmed to be underexpressed in MM compared to normal plasma cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDH6 antibodyPathways associated with anti-CDH6 antibody
 Reference Product  PubMed Publications
 CDH7 antibody  >3 publications with CDH6 and CDH7
 CDH10 antibody  >1 publications with CDH6 and CDH10
 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
Diseases associated with anti-CDH6 antibodyOrgans/Tissues associated with anti-CDH6 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with CDH6 and Neoplasms
 Neural Tube Defects Antibodies  >1 publications with CDH6 and Neural Tube Defects
 Head and Neck Neoplasms Antibodies  >1 publications with CDH6 and Head and Neck Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with CDH6 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >1 publications with CDH6 and Adenocarcinoma
 Ovarian Diseases Antibodies  >1 publications with CDH6 and Ovarian Diseases
 Carcinoma in Situ Antibodies  >1 publications with CDH6 and Carcinoma in Situ
 Edema Antibodies  >1 publications with CDH6 and Edema
 Craniofacial Abnormalities Antibodies  >1 publications with CDH6 and Craniofacial Abnormalities
 Liver Neoplasms Antibodies  >1 publications with CDH6 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with CDH6 and Brain
 Embryonic Tissue Antibodies  >3 publications with CDH6 and Embryonic Tissue
 Eye Antibodies  >2 publications with CDH6 and Eye
 Lung Antibodies  >2 publications with CDH6 and Lung
 Prostate Antibodies  >1 publications with CDH6 and Prostate
 Kidney Antibodies  >1 publications with CDH6 and Kidney
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