NP_000209.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
potassium voltage-gated channel subfamily KQT member 1 isoform 1
NCBI Official Synonym Full Names
potassium voltage-gated channel, KQT-like subfamily, member 1
NCBI Official Synonym Symbols
LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1 [Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; kidney and cardiac voltage dependend K+ channel; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 1
UniProt Synonym Protein Names
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1
UniProt Synonym Gene Names
UniProt Entry Name
KCNQ1_HUMAN
NCBI Summary for KCNQ1
This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for KCNQ1
Kv7.1: a voltage-gated potassium channel protein required for the repolarization phase of the cardiac action potential. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. Three alternatively spliced isoforms have been described.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: voltage-gated potassium channel complex; cytoplasmic vesicle membrane; basolateral plasma membrane; lysosome; early endosome; late endosome; plasma membrane
Molecular Function: calmodulin binding; protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; protein phosphatase 1 binding
Biological Process: synaptic transmission; genetic imprinting; sensory perception of sound; positive regulation of heart rate; gene silencing; regulation of heart contraction; cardiac muscle contraction
Disease: Jervell And Lange-nielsen Syndrome 1; Beckwith-wiedemann Syndrome; Atrial Fibrillation, Familial, 3; Short Qt Syndrome 2; Long Qt Syndrome 1
Product References and Citations for anti-KCNQ1 antibody
1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.:Sunderland, MA USA. 2. www.iochannels.org 3. Lang F., Vallon V., Knipper M., Wagenmann P. (2007) Am J Physiol. 293(4): C1187-1208. 4. Kurokawa J., et al. (2009) Channels (Austin). 3(1): 16-24. 5. Silva J., and Rudy Y. (2005) Circulation. 112(10): 1384- 1391.
Research Articles on KCNQ1
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Products associated with anti-KCNQ1 antibody
Pathways associated with anti-KCNQ1 antibody
Diseases associated with anti-KCNQ1 antibody
Disease Name |
Pubmed Publications |
Arrhythmias, Cardiac Antibodies |
>649 publications with KCNQ1 and Arrhythmias, Cardiac |
Heart Diseases Antibodies |
>633 publications with KCNQ1 and Heart Diseases |
Long QT Syndrome Antibodies |
>614 publications with KCNQ1 and Long QT Syndrome |
Death, Sudden, Cardiac Antibodies |
>253 publications with KCNQ1 and Death, Sudden, Cardiac |
Syncope Antibodies |
>123 publications with KCNQ1 and Syncope |
Tachycardia Antibodies |
>89 publications with KCNQ1 and Tachycardia |
Diabetes Mellitus, Type 2 Antibodies |
>88 publications with KCNQ1 and Diabetes Mellitus, Type 2 |
Romano-Ward Syndrome Antibodies |
>85 publications with KCNQ1 and Romano-Ward Syndrome |
Tachycardia, Ventricular Antibodies |
>85 publications with KCNQ1 and Tachycardia, Ventricular |
Jervell-Lange Nielsen Syndrome Antibodies |
>74 publications with KCNQ1 and Jervell-Lange Nielsen Syndrome |
Organs/Tissues associated with anti-KCNQ1 antibody
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