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anti-KDM6A antibody :: Mouse anti-Human KDM6A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850395
Testing Data
Unit / Price
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KDM6A, Monoclonal Antibody

★Popular Item★
 Also Known As   

KDM6A Antibody

 Product Gene Name   

anti-KDM6A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 300867
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Protein G-Sepharose affinity purified
 Form/Format    Liquid
 Concentration    50ug/50ul (lot specific)
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 Relevance    KDM6A is an 154 kDa ubiquitously transcribed X chromosome tetraticopeptide repeat protein that is predicted to interact with TLE1. KDM6A contains a jumonji C domain and specifically demethylates di and tri methyl histone H3 at K27.
 Perservative    0.02% Sodium Azide, 50% glycerol, 1% BSA, PBS, pH7.4.
 Immunogen    Recombinant fragment of human KDM6A (N-terminus).
 Cellular Localization    Nucleus
 Pathway    X chromosome tetraticopeptide repeat protein
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles
 Other Notes    Small volumes of anti-KDM6A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KDM6A antibody

   Background: Mouse monoclonal IgG to KDM6A
 Product Categories/Family for anti-KDM6A antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-KDM6A antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-KDM6A antibody    ELISA: 1/5000 - 1/20000, WB: 1/100-1/2000
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 Testing Data of anti-KDM6A antibody    KDM6A antibody at 1/2000 dilution interacts with recombinant KDM6A protein with a GST tag. Predicted band size: 40Kda. Observed band size: 40Kda.
anti-KDM6A antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for KDM6A. It may not necessarily be applicable to this product.
 NCBI GI #    189011543
 NCBI GeneID    7403
 NCBI Accession #    NP_066963.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021140 [Other Products]
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 UniProt Secondary Accession #    Q52LL9; Q5JVQ7 [Other Products]
 UniProt Related Accession #    O15550 [Other Products]
 Molecular Weight    154,177 Da
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 NCBI Official Full Name    Homo sapiens lysine (K)-specific demethylase 6A (KDM6A), mRNA
 NCBI Official Synonym Full Names    lysine (K)-specific demethylase 6A
 NCBI Official Symbol    KDM6A [Similar Products]
 NCBI Official Synonym Symbols   
UTX; KABUK2; bA386N14.2
[Similar Products]
 NCBI Protein Information    lysine-specific demethylase 6A; histone demethylase UTX; ubiquitously-transcribed TPR gene on the X chromosome; ubiquitously transcribed tetratricopeptide repeat protein X-linked; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))
 UniProt Protein Name    Lysine-specific demethylase 6A
 UniProt Synonym Protein Names   
Histone demethylase UTX; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein
 Protein Family    Lysine-specific demethylase
 UniProt Gene Name    KDM6A [Similar Products]
 UniProt Synonym Gene Names    UTX [Similar Products]
 UniProt Entry Name    KDM6A_HUMAN
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 NCBI Summary for KDM6A    This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
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 UniProt Comments for KDM6A    UTX: a nuclear protein that contains 8 tetratrico peptide repeat (TPRs). Processes involving TPR proteins include cell-cycle control, transcription repression, stress response, protein kinase inhibition, mitochondrial and peroxisomal protein transport and neurogenesis.

Protein type: EC 1.14.11.-; Oxidoreductase

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus

Molecular Function: identical protein binding; dioxygenase activity; metal ion binding

Biological Process: heart morphogenesis; notochord morphogenesis; respiratory system process; establishment and/or maintenance of chromatin architecture; regulation of gene expression; in utero embryonic development; multicellular organism growth; histone H3-K4 methylation; neural tube closure; mesodermal cell differentiation; Wnt receptor signaling pathway through beta-catenin; somite rostral/caudal axis specification

Disease: Kabuki Syndrome 2; Kabuki Syndrome 1
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 Research Articles on KDM6A    1. Both Ezh2 and Kdm6a were shown to affect expression of master regulatory genes involved in adipogenesis and osteogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KDM6A antibodyPathways associated with anti-KDM6A antibody
 Reference Product  PubMed Publications
 MLL2 antibody  >22 publications with KDM6A and MLL2
 KDM5C antibody  >8 publications with KDM6A and KDM5C
 MLL3 antibody  >5 publications with KDM6A and MLL3
 RBL2 antibody  >1 publications with KDM6A and RBL2
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HDMs Demethylate Histones Pathway antibodies  HDMs Demethylate Histones Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with anti-KDM6A antibodyOrgans/Tissues associated with anti-KDM6A antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >10 publications with KDM6A and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >7 publications with KDM6A and Abnormalities, Multiple
 Kidney Diseases Antibodies  >7 publications with KDM6A and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with KDM6A and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >2 publications with KDM6A and Lung Neoplasms
 Inflammation Antibodies  >2 publications with KDM6A and Inflammation
 Neoplasms, Experimental Antibodies  >2 publications with KDM6A and Neoplasms, Experimental
 Neural Tube Defects Antibodies  >1 publications with KDM6A and Neural Tube Defects
 Esophageal Squamous Cell Carcinoma Antibodies  >1 publications with KDM6A and Esophageal Squamous Cell Carcinoma
 Carcinoma, Adenoid Cystic Antibodies  >1 publications with KDM6A and Carcinoma, Adenoid Cystic
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >8 publications with KDM6A and Kidney
 Brain Antibodies  >6 publications with KDM6A and Brain
 Heart Antibodies  >4 publications with KDM6A and Heart
 Prostate Antibodies  >4 publications with KDM6A and Prostate
 Muscle Antibodies  >4 publications with KDM6A and Muscle
 Skin Antibodies  >2 publications with KDM6A and Skin
 Blood Antibodies  >2 publications with KDM6A and Blood
 Lung Antibodies  >2 publications with KDM6A and Lung
 Bone Antibodies  >2 publications with KDM6A and Bone
 Liver Antibodies  >2 publications with KDM6A and Liver
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