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anti-KHSRP antibody :: Mouse anti-Human KHSRP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6010890
Unit / Price
0.05 mg  /  $760 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KHSRP, Monoclonal Antibody

★Popular Item★
 Also Known As   

KHSRP (KH Type-splicing Regulatory Protein, KSRP, Far Upstream Element-binding Protein 2, FUSE-binding Protein 2, FBP2, FUBP2, MGC99676, p75)

 Product Synonym Names    Anti -KHSRP (KH Type-splicing Regulatory Protein, KSRP, Far Upstream Element-binding Protein 2, FUSE-binding Protein 2, FBP2, FUBP2, MGC99676, p75)
 Product Gene Name   

anti-KHSRP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (6413115..6424822, complement). Location: 19p13.3
 OMIM    603445
 3D Structure    ModBase 3D Structure for Q92945
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 Clonality    Monoclonal
 Isotype    IgG2b,k
 Clone Number    4C10
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human KHSRP.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4.
 Concentration    0.4mg/ml (lot specific)
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 Immunogen    Recombinant corresponding to aa151-240 from human KHSRP with GST tag. MW of the GST tag alone is 26kD.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-KHSRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KHSRP antibody

   KHSRP binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). It is a part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. It may interact with single-stranded DNA from the far-upstream element (FUSE) and activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
 Product Categories/Family for anti-KHSRP antibody    Antibodies; Abs to RNA Processing
 Applications Tested/Suitable for anti-KHSRP antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-KHSRP antibody    Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml. Requires HIER using sodium citrate buffer pH 6.0
Optimal dilutions to be determined by the researcher.
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 Immunohistochemistry of anti-KHSRP antibody    Immunohistochemistry analysis of Formalin-Fixed, Paraffin-Embedded (FFPE) of human Testis
anti-KHSRP antibody Immunohistochemistry (IHC) image
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 Immunohistochemistry of anti-KHSRP antibody    Immunohistochemistry analysis of Formalin-Fixed, Paraffin-Embedded (FFPE) human Tonsil
anti-KHSRP antibody Immunohistochemistry (IHC) image
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  ELISA Analysis of anti-KHSRP antibody    Dectection limit for recombinant GST tagged KHSRP is ~0.3ng/ml as a capture antibody.
anti-KHSRP antibody   ELISA Analysis image
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NCBI/Uniprot data below describe general gene information for KHSRP. It may not necessarily be applicable to this product.
 NCBI GI #    54648253
 NCBI GeneID    8570
 NCBI Accession #    AAH85004.1 [Other Products]
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 UniProt Primary Accession #    Q92945 [Other Products]
 UniProt Secondary Accession #    O00301; Q59EZ9; Q5U4P6; Q9UNT5; Q9UQH5 [Other Products]
 UniProt Related Accession #    Q92945 [Other Products]
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 NCBI Official Full Name    KHSRP protein
 NCBI Official Synonym Full Names    KH-type splicing regulatory protein
 NCBI Official Symbol    KHSRP [Similar Products]
 NCBI Official Synonym Symbols   
FBP2; KSRP; FUBP2
[Similar Products]
 NCBI Protein Information    far upstream element-binding protein 2; p75; FUSE binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein
 UniProt Protein Name    Far upstream element-binding protein 2
 UniProt Synonym Protein Names   
KH type-splicing regulatory protein; KSRP; p75
 Protein Family    Far upstream element-binding protein
 UniProt Gene Name    KHSRP [Similar Products]
 UniProt Synonym Gene Names    FUBP2; FUSE-binding protein 2; KSRP [Similar Products]
 UniProt Entry Name    FUBP2_HUMAN
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 NCBI Summary for KHSRP    The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
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 UniProt Comments for KHSRP    KHSRP: an RNA binding and processing protein that binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3' untranslated regions, possibly by recruiting degradation machinery to ARE-containing mRNAs. Interacts with APC which is part of the apolipoprotein B mRNA editing enzyme complex. The interaction is not required for activity of the catalytic component, APOBEC1, but may confer stability on the complex.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; membrane; stress granule; cytosol

Molecular Function: mRNA binding; DNA binding

Biological Process: RNA splicing, via transesterification reactions; mRNA transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA splicing; mRNA catabolic process; gene expression; mRNA processing
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 Research Articles on KHSRP    1. KSRP induces enhanced processing of pri- and pre-miR-155 in cystic fibrosis lung epithelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KHSRP antibodyPathways associated with anti-KHSRP antibody
 Reference Product  PubMed Publications
 ELAVL1 antibody  >5 publications with KHSRP and ELAVL1
 HNRNPH1 antibody  >1 publications with KHSRP and HNRNPH1
 PARN antibody  >1 publications with KHSRP and PARN
 Products by Pathway  Pathway Diagram
 Activation Of Genes By ATF4 Pathway antibodies  Activation Of Genes By ATF4 Pathway Diagram
 Destabilization Of MRNA By KSRP Pathway antibodies  Destabilization Of MRNA By KSRP Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 PERK Regulated Gene Expression Pathway antibodies  PERK Regulated Gene Expression Pathway Diagram
 Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies  Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram
 Unfolded Protein Response Pathway antibodies  Unfolded Protein Response Pathway Diagram
Diseases associated with anti-KHSRP antibodyOrgans/Tissues associated with anti-KHSRP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with KHSRP and Neoplasms
 Nervous System Diseases Antibodies  >5 publications with KHSRP and Nervous System Diseases
 Inflammation Antibodies  >4 publications with KHSRP and Inflammation
 Carcinoma Antibodies  >3 publications with KHSRP and Carcinoma
 Liver Neoplasms Antibodies  >2 publications with KHSRP and Liver Neoplasms
 Kidney Diseases Antibodies  >2 publications with KHSRP and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with KHSRP and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >1 publications with KHSRP and Cardiovascular Diseases
 Hyperplasia Antibodies  >1 publications with KHSRP and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with KHSRP and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with KHSRP and Brain
 Liver Antibodies  >6 publications with KHSRP and Liver
 Blood Antibodies  >5 publications with KHSRP and Blood
 Nerve Antibodies  >4 publications with KHSRP and Nerve
 Muscle Antibodies  >3 publications with KHSRP and Muscle
 Bone Antibodies  >3 publications with KHSRP and Bone
 Lung Antibodies  >3 publications with KHSRP and Lung
 Kidney Antibodies  >2 publications with KHSRP and Kidney
 Ovary Antibodies  >1 publications with KHSRP and Ovary
 Skin Antibodies  >1 publications with KHSRP and Skin
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