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anti-KIN antibody :: Mouse anti-Human KIN Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120415
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KIN, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human KIN

 Product Synonym Names    Homo sapiens KIN, antigenic determinant of recA protein homolog (mouse) (KIN), mRNA.; BTCD; KIN17
 Product Gene Name   

anti-KIN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601720
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2490D1a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-KIN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KIN antibody

   The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.[NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-KIN antibody   

Dot Blot (DB)

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 Quality Control of anti-KIN antibody    Western blot analysis of immunized recombinant protein, using anti-KIN monoclonal antibody.
anti-KIN antibody Quality Control image
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 Quality Control #2 of anti-KIN antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-KIN antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for KIN. It may not necessarily be applicable to this product.
 NCBI GI #    359807087
 NCBI GeneID    22944
 NCBI Accession #    NP_036443.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012311 [Other Products]
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 UniProt Secondary Accession #    B4DX32 [Other Products]
 UniProt Related Accession #    O60870 [Other Products]
 Molecular Weight    43,261 Da
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 NCBI Official Full Name    Homo sapiens Kin17 DNA and RNA binding protein (KIN), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    Kin17 DNA and RNA binding protein
 NCBI Official Symbol    KIN [Similar Products]
 NCBI Official Synonym Symbols   
BTCD; Rts2; KIN17
[Similar Products]
 NCBI Protein Information    DNA/RNA-binding protein KIN17; KIN, antigenic determinant of recA protein homolog; binding to curved DNA
 UniProt Protein Name    DNA/RNA-binding protein KIN17
 UniProt Synonym Protein Names   
Binding to curved DNA; KIN, antigenic determinant of recA protein homolog
 Protein Family    Kinin
 UniProt Gene Name    KIN [Similar Products]
 UniProt Entry Name    KIN17_HUMAN
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 NCBI Summary for KIN    The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
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 UniProt Comments for KIN    KIN: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro. Belongs to the KIN17 family.

Protein type: DNA replication; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 10p14

Cellular Component: nuclear matrix; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: DNA binding; RNA binding; metal ion binding; double-stranded DNA binding

Biological Process: viral reproduction; mRNA processing; DNA repair; DNA replication; response to DNA damage stimulus; DNA recombination
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 Research Articles on KIN    1. overexpression of KIN rendered colorectal cancer cells enriching cancer stem cell (CSC) markers and CSC phenotype, and silencing KIN reduced CSC markers and CSC phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KIN antibodyDiseases associated with anti-KIN antibody
 Reference Product  PubMed Publications
 IDE antibody  >4 publications with KIN and IDE
 RPA1 antibody  >2 publications with KIN and RPA1
 CCND1 antibody  >1 publications with KIN and CCND1
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >334 publications with KIN and Cardiovascular Diseases
 Mental Disorders Antibodies  >274 publications with KIN and Mental Disorders
 Immune System Diseases Antibodies  >198 publications with KIN and Immune System Diseases
 Heart Diseases Antibodies  >186 publications with KIN and Heart Diseases
 Lung Diseases Antibodies  >169 publications with KIN and Lung Diseases
 Liver Diseases Antibodies  >99 publications with KIN and Liver Diseases
 Adenocarcinoma Antibodies  >98 publications with KIN and Adenocarcinoma
 Hemorrhage Antibodies  >62 publications with KIN and Hemorrhage
 Liver Neoplasms Antibodies  >62 publications with KIN and Liver Neoplasms
 Breast Neoplasms Antibodies  >57 publications with KIN and Breast Neoplasms
Organs/Tissues associated with anti-KIN antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >505 publications with KIN and Blood
 Muscle Antibodies  >427 publications with KIN and Muscle
 Brain Antibodies  >374 publications with KIN and Brain
 Liver Antibodies  >175 publications with KIN and Liver
 Lung Antibodies  >174 publications with KIN and Lung
 Kidney Antibodies  >102 publications with KIN and Kidney
 Pancreas Antibodies  >96 publications with KIN and Pancreas
 Nerve Antibodies  >89 publications with KIN and Nerve
 Skin Antibodies  >82 publications with KIN and Skin
 Stomach Antibodies  >59 publications with KIN and Stomach
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