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anti-KLF4 antibody :: Mouse KLF4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150014
Western Blot (WB)
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KLF4, Monoclonal Antibody

 Also Known As   

KLF4 Antibody [4E5C3]

 Product Synonym Names    KLF4 Antibody [4E5C3] : EZF; GKLF; Kruppel-like factor 4 (gut)
 Product Gene Name   

anti-KLF4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602253
 3D Structure    ModBase 3D Structure for O43474
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    4E5C3
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least three isoforms of KLF4 are known to exist; this antibody will detect all three. KLF4 antibody will not cross-react with other Kruppel-like family members.
 Purity/Purification    KLF4 Monoclonal Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    KLF4 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human KLF4.
 Buffer    KLF4 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    KLF4 monoclonal antibody can be stored at -20 degree C, stable for one year.
 Other Notes    Small volumes of anti-KLF4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-KLF4 antibody

   KLF4 Monoclonal Antibody: KLF4 is a transcription factor that functions as both a transcriptional activator and repressor to regulate proliferation and differentiation of multiple cell types. The role of KLF4 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing KLF4 and the transcription factors POU5F1, Sox2, and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing KLF4, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. KLF4 interacts directly with POU5F1 and Sox2 in iPS and ES cells and activates the target gene NANOG.
 Applications Tested/Suitable for anti-KLF4 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-KLF4 antibody    KLF4 antibody can be used for detection of KLF4 by Western blot at 1 mug/mL.
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 Western Blot (WB) of anti-KLF4 antibody    Western blot analysis of KLF4 in mouse liver tissue lysate with KLF4 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
anti-KLF4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for KLF4. It may not necessarily be applicable to this product.
 NCBI GI #    21410813
 NCBI GeneID    9314
 NCBI Accession #    AAH30811 [Other Products]
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 UniProt Primary Accession #    O43474 [Other Products]
 UniProt Secondary Accession #    P78338; Q5T3J8; Q5T3J9; Q8N717; Q9UNP3; B2R8S4; B3KT79; L0R3I6; L0R4N5 [Other Products]
 UniProt Related Accession #    O43474 [Other Products]
 Molecular Weight    6,489 Da
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 NCBI Official Full Name    KLF4 protein
 NCBI Official Synonym Full Names    Kruppel-like factor 4 (gut)
 NCBI Official Symbol    KLF4 [Similar Products]
 NCBI Official Synonym Symbols   
EZF; GKLF
[Similar Products]
 NCBI Protein Information    Krueppel-like factor 4; gut-enriched krueppel-like factor; epithelial zinc finger protein EZF; endothelial Kruppel-like zinc finger protein
 UniProt Protein Name    Krueppel-like factor 4
 UniProt Synonym Protein Names   
Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor
 Protein Family    Krueppel-like factor
 UniProt Gene Name    KLF4 [Similar Products]
 UniProt Synonym Gene Names    EZF; GKLF [Similar Products]
 UniProt Entry Name    KLF4_HUMAN
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 UniProt Comments for KLF4    KLF4: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain). Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 9q31

Cellular Component: nucleoplasm; transcription factor complex; nuclear chromatin

Molecular Function: protein binding; zinc ion binding; double-stranded DNA binding; phosphoinositide 3-kinase regulator activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; fat cell differentiation; post-embryonic camera-type eye development; positive regulation of nitric oxide biosynthetic process; negative regulation of smooth muscle cell proliferation; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; negative regulation of interleukin-8 biosynthetic process; negative regulation of muscle hyperplasia; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of protein metabolic process; positive regulation of hemoglobin biosynthetic process; regulation of phosphoinositide 3-kinase activity; negative regulation of cell proliferation; post-embryonic hemopoiesis; epidermis morphogenesis; regulation of cell differentiation; negative regulation of protein kinase B signaling cascade; response to retinoic acid; negative regulation of heterotypic cell-cell adhesion; stem cell maintenance; positive regulation of telomerase activity; inhibition of NF-kappaB transcription factor; negative regulation of inflammatory response; epidermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; mesodermal cell fate determination; negative regulation of phosphoinositide 3-kinase cascade
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 Research Articles on KLF4    1. This study identified a novel miR-2909-KLF4 molecular axis able to differentiate between the pathogeneses of pediatric B- and T-cell ALLs, and which may represent a new diagnostic/prognostic marker.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KLF4 antibodyPathways associated with anti-KLF4 antibody
 Reference Product  PubMed Publications
 SP1 antibody  >43 publications with KLF4 and SP1
 CTNNB1 antibody  >33 publications with KLF4 and CTNNB1
 TGFB1 antibody  >15 publications with KLF4 and TGFB1
 TP53 antibody  >15 publications with KLF4 and TP53
 HDAC2 antibody  >11 publications with KLF4 and HDAC2
 RELA antibody  >4 publications with KLF4 and RELA
 KAT5 antibody  >2 publications with KLF4 and KAT5
 EP300 antibody  >2 publications with KLF4 and EP300
 CREBBP antibody  >1 publications with KLF4 and CREBBP
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 SRF And MiRs In Smooth Muscle Differentiation And Proliferation Pathway antibodies  SRF And MiRs In Smooth Muscle Differentiation And Proliferation Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Synthesis, Secretion, And Deacylation Of Ghrelin Pathway antibodies  Synthesis, Secretion, And Deacylation Of Ghrelin Pathway Diagram
 Transcriptional Regulation Of Pluripotent Stem Cells Pathway antibodies  Transcriptional Regulation Of Pluripotent Stem Cells Pathway Diagram
 Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies  Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram
Diseases associated with anti-KLF4 antibodyOrgans/Tissues associated with anti-KLF4 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >79 publications with KLF4 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >76 publications with KLF4 and Nervous System Diseases
 Disease Models, Animal Antibodies  >56 publications with KLF4 and Disease Models, Animal
 Inflammation Antibodies  >53 publications with KLF4 and Inflammation
 Breast Neoplasms Antibodies  >39 publications with KLF4 and Breast Neoplasms
 Heart Diseases Antibodies  >34 publications with KLF4 and Heart Diseases
 Carcinoma, Squamous Cell Antibodies  >25 publications with KLF4 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >21 publications with KLF4 and Neoplasms, Experimental
 Lung Diseases Antibodies  >20 publications with KLF4 and Lung Diseases
 Hyperplasia Antibodies  >18 publications with KLF4 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >203 publications with KLF4 and Embryonic Tissue
 Skin Antibodies  >126 publications with KLF4 and Skin
 Vascular Antibodies  >112 publications with KLF4 and Vascular
 Heart Antibodies  >81 publications with KLF4 and Heart
 Brain Antibodies  >72 publications with KLF4 and Brain
 Liver Antibodies  >54 publications with KLF4 and Liver
 Lung Antibodies  >48 publications with KLF4 and Lung
 Intestine Antibodies  >46 publications with KLF4 and Intestine
 Eye Antibodies  >43 publications with KLF4 and Eye
 Kidney Antibodies  >31 publications with KLF4 and Kidney
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