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anti-KLF4 antibody :: Mouse anti-Human KLF4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200128
Western Blot (WB)
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KLF4, Monoclonal Antibody

 Also Known As   

KLF4 antibody

 Product Synonym Names    krueppel-like factor 4; EZF; GKLF
 Product Gene Name   

anti-KLF4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF022184 mRNA
 3D Structure    ModBase 3D Structure for O43474
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 Clonality    Monoclonal
 Isotype    IgG1, k
 Clone Number    AT4E6
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human kLF4 (1-170aa) purified from E. coli
 Clone Note    Anti-human kLF4 mAb, clone AT4E6, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human kLF4 protein.
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 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-KLF4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KLF4 antibody

   kLF4, which is also known as the gut-enriched kruppel-like factor (GkLF), is a zinc finger-containing transcription factor that belongs to the kruppel-like family of transcription factors. kLF4 plays important roles during the proliferation and differentiation of epithelial cells. Especially, it is found predominantly in gut and has been shown to be expressed during growth arrest. kLF4 is also involved in cell cycle control since expression of kLF4 inhibits DNA synthesis by blocking the G1/S phase of the cell cycle.
 Product Categories/Family for anti-KLF4 antibody    Enzymes & Proteases
 Applications Tested/Suitable for anti-KLF4 antibody   

ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-KLF4 antibody    WB: 1:1000 ~ 2000.
Recommended starting dilution is 1:1000.
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 Western Blot (WB) of anti-KLF4 antibody    The Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human KLF4 antibody (1:3000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: A549 cell lysate Lane 2.: HeLa cell lysate
anti-KLF4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for KLF4. It may not necessarily be applicable to this product.
 NCBI GI #    194248077
 NCBI GeneID    9314
 NCBI Accession #    NP_004226.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_004235.5 [Other Products]
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 UniProt Primary Accession #    O43474 [Other Products]
 UniProt Secondary Accession #    P78338; Q5T3J8; Q5T3J9; Q8N717; Q9UNP3; B2R8S4; B3KT79; L0R3I6; L0R4N5 [Other Products]
 UniProt Related Accession #    O43474 [Other Products]
 Molecular Weight    6,489 Da
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 NCBI Official Full Name    Krueppel-like factor 4 isoform 2
 NCBI Official Synonym Full Names    Kruppel like factor 4
 NCBI Official Symbol    KLF4 [Similar Products]
 NCBI Official Synonym Symbols   
EZF; GKLF
[Similar Products]
 NCBI Protein Information    Krueppel-like factor 4
 UniProt Protein Name    Krueppel-like factor 4
 UniProt Synonym Protein Names   
Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor
 Protein Family    Krueppel-like factor
 UniProt Gene Name    KLF4 [Similar Products]
 UniProt Synonym Gene Names    EZF; GKLF [Similar Products]
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 NCBI Summary for KLF4    This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
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 UniProt Comments for KLF4    Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
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Product References and Citations for anti-KLF4 antibody

   Yan FF, et al., (2008) Med Hypotheses. 70 (4):845-7; Cho YG, et al., (2007) APMIS. 115 (7):802-8
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 Research Articles on KLF4    1. Data suggest that KLF4 could promote cell senescence through a complex network: miR-203, survivin, and p21, which were all regulated by overexpression of KLF4 and contributed to cell senescence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-KLF4 antibodyDiseases associated with anti-KLF4 antibody
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Mesodermal Commitment Pathway antibodies  Mesodermal Commitment Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Preimplantation Embryo Pathway antibodies  Preimplantation Embryo Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 SRF And MiRs In Smooth Muscle Differentiation And Proliferation Pathway antibodies  SRF And MiRs In Smooth Muscle Differentiation And Proliferation Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Synthesis, Secretion, And Deacylation Of Ghrelin Pathway antibodies  Synthesis, Secretion, And Deacylation Of Ghrelin Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >138 publications with KLF4 and Nervous System Diseases
 Disease Models, Animal Antibodies  >110 publications with KLF4 and Disease Models, Animal
 Inflammation Antibodies  >97 publications with KLF4 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >72 publications with KLF4 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >71 publications with KLF4 and Breast Neoplasms
 Heart Diseases Antibodies  >54 publications with KLF4 and Heart Diseases
 Liver Diseases Antibodies  >50 publications with KLF4 and Liver Diseases
 Carcinoma, Squamous Cell Antibodies  >44 publications with KLF4 and Carcinoma, Squamous Cell
 Liver Neoplasms Antibodies  >41 publications with KLF4 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >39 publications with KLF4 and Neoplasms, Experimental
Organs/Tissues associated with anti-KLF4 antibody
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >273 publications with KLF4 and Embryonic Tissue
 Vascular Antibodies  >198 publications with KLF4 and Vascular
 Skin Antibodies  >176 publications with KLF4 and Skin
 Heart Antibodies  >129 publications with KLF4 and Heart
 Brain Antibodies  >126 publications with KLF4 and Brain
 Liver Antibodies  >107 publications with KLF4 and Liver
 Lung Antibodies  >91 publications with KLF4 and Lung
 Eye Antibodies  >82 publications with KLF4 and Eye
 Intestine Antibodies  >65 publications with KLF4 and Intestine
 Kidney Antibodies  >54 publications with KLF4 and Kidney
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