NP_071925.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 65 kDa Predicted: 66 kDa
NCBI Official Full Name
kelch-like protein 25
NCBI Official Synonym Full Names
kelch like family member 25
NCBI Official Synonym Symbols
NCBI Protein Information
kelch-like protein 25
UniProt Protein Name
Kelch-like protein 25
UniProt Synonym Protein Names
Ectoderm-neural cortex protein 2; ENC-2
UniProt Synonym Gene Names
UniProt Comments for KLHL25
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Research Articles on KLHL25
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Products associated with anti-KLHL25 antibody
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