NP_001129504.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
kallikrein-11 isoform 1
NCBI Official Synonym Full Names
kallikrein-related peptidase 11
NCBI Official Synonym Symbols
NCBI Protein Information
kallikrein-11; hK11; hippostasin; kallikrein 11; serine protease 20; trypsin-like protease
UniProt Protein Name
Kallikrein-11
UniProt Synonym Protein Names
Hippostasin; Serine protease 20; Trypsin-like protease
UniProt Synonym Gene Names
UniProt Entry Name
KLK11_HUMAN
NCBI Summary for KLK11
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.[provided by RefSeq, Nov 2009]
UniProt Comments for KLK11
Function: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. Ref.2 Ref.11
Subcellular location: Isoform 1: Secreted Ref.6. Isoform 2: Golgi apparatus Ref.6.
Tissue specificity: Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level). Ref.2 Ref.11
Post-translational modification: About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.
Research Articles on KLK11
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Products associated with anti-KLK11 antibody
Diseases associated with anti-KLK11 antibody
Organs/Tissues associated with anti-KLK11 antibody
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