NP_001002231.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,301 Da
NCBI Official Full Name
kallikrein-2 isoform 2 preproprotein
NCBI Official Synonym Full Names
kallikrein related peptidase 2
NCBI Protein Information
kallikrein-2
UniProt Protein Name
Kallikrein-2
UniProt Synonym Protein Names
Glandular kallikrein-1; hGK-1; Tissue kallikrein-2
UniProt Synonym Gene Names
NCBI Summary for KLK2
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
UniProt Comments for KLK2
KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.21.35; Protease
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: extracellular region
Molecular Function: serine-type endopeptidase activity
Biological Process: extracellular matrix disassembly; proteolysis
Research Articles on KLK2
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Products associated with anti-KLK2 antibody
Pathways associated with anti-KLK2 antibody
Diseases associated with anti-KLK2 antibody
Organs/Tissues associated with anti-KLK2 antibody
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