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anti-KLK3 antibody :: Mouse anti-Human Kallikrein 3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690547 anti-KLK3 antibody
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kallikrein 3 (KLK3), Monoclonal Antibody

 Also Known As   

Mouse Anti-Human Kallikrein 3

 Product Synonym Names    KLK3; APS; PSA; hK3; KLK2A1
 Product Gene Name   

anti-KLK3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.10 (50854915..50860764). Location: 19q13.41
 OMIM    176820
 3D Structure    ModBase 3D Structure for P07288
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    (5F28)
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Kallikrein-3.
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-KLK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-KLK3 antibody

   The human tissue kallikrein (KLK) gene family contains 15 members that play important roles in cancer. Notably, kallikrein-1, also known as tissue kallikrein, cleaves kininogen to release the vasoactive kinin peptide, bradykinin or lysyl-bradykinin. Kallikrein-3, called prostate specific antigen (PSA), is an established tumor marker that aids in the diagnosis, staging, and follow up of prostate cancer. Kallikrein-4 is specifically expressed in the prostate and over-expressed in prostate cancer. Kallikrein-5 is widely expressed but found at high levels in skin, breast, brain and testis; over-expression is an indicator of poor prognosis in ovarian cancer. Kallikrein-8 is expressed in the brain and is a novel marker of ovarian and cervical cancer.
 Applications Tested/Suitable for anti-KLK3 antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for KLK3. It may not necessarily be applicable to this product.
 NCBI GI #    71834853
 NCBI GeneID    354
 NCBI Accession #    NP_001025218.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001030047.1 [Other Products]
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 UniProt Primary Accession #    P07288 [Other Products]
 UniProt Secondary Accession #    Q15096; Q16272; Q86TG8; Q8IXI4; C9JXH3; G3V0H4; G3XAE3 [Other Products]
 UniProt Related Accession #    P07288 [Other Products]
 Molecular Weight    28,741 Da [Similar Products]
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 NCBI Official Full Name    prostate-specific antigen isoform 3 preproprotein
 NCBI Official Synonym Full Names    kallikrein-related peptidase 3
 NCBI Official Symbol    KLK3 [Similar Products]
 NCBI Official Synonym Symbols   
APS; PSA; hK3; KLK2A1
[Similar Products]
 NCBI Protein Information    prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen
 UniProt Protein Name    Prostate-specific antigen
 UniProt Synonym Protein Names   
Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase
 Protein Family    Glandular kallikrein
 UniProt Gene Name    KLK3 [Similar Products]
 UniProt Synonym Gene Names    APS; PSA; Seminin [Similar Products]
 UniProt Entry Name    KLK3_HUMAN
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 NCBI Summary for KLK3    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KLK3    PSA: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein type: EC 3.4.21.77; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region; extracellular space; nucleus; protein complex

Molecular Function: endopeptidase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; protein binding; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: antibacterial peptide production; cellular protein metabolic process; proteolysis
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 Research Articles on KLK3    1. Serum prostate-specific antigen levels are not affected by acute myocardial infarction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KLK3 antibodyPathways associated with anti-KLK3 antibody
 Reference Product  PubMed Publications
 TP53 antibody  >2 publications with KLK3 and TP53
 ERBB2 antibody  >2 publications with KLK3 and ERBB2
 IL6 antibody  >1 publications with KLK3 and IL6
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Diseases associated with anti-KLK3 antibodyOrgans/Tissues associated with anti-KLK3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >92 publications with KLK3 and Neoplasms
 Prostatic Neoplasms Antibodies  >69 publications with KLK3 and Prostatic Neoplasms
 Adenocarcinoma Antibodies  >14 publications with KLK3 and Adenocarcinoma
 Breast Neoplasms Antibodies  >13 publications with KLK3 and Breast Neoplasms
 Disease Progression Antibodies  >10 publications with KLK3 and Disease Progression
 Hyperplasia Antibodies  >8 publications with KLK3 and Hyperplasia
 Kidney Diseases Antibodies  >6 publications with KLK3 and Kidney Diseases
 Ovarian Neoplasms Antibodies  >6 publications with KLK3 and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >6 publications with KLK3 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >5 publications with KLK3 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >122 publications with KLK3 and Prostate
 Brain Antibodies  >5 publications with KLK3 and Brain
 Salivary Gland Antibodies  >4 publications with KLK3 and Salivary Gland
 Bone Antibodies  >3 publications with KLK3 and Bone
 Muscle Antibodies  >2 publications with KLK3 and Muscle
 Nerve Antibodies  >2 publications with KLK3 and Nerve
 Adrenal Gland Antibodies  >1 publications with KLK3 and Adrenal Gland
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