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anti-KLK7 antibody :: Mouse anti-Human Kallikrein 7 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690083 anti-KLK7 antibody
Unit / Price
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kallikrein 7 (KLK7), Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti-Human Kallikrein 7

 Product Synonym Names    KLK7; hK7; SCCE; PRSS6
 Product Gene Name   

anti-KLK7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.10 (50976479..50984064, complement). Location: 19q13.41
 OMIM    604438
 3D Structure    ModBase 3D Structure for P49862
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    (5J28)
 Host    Mouse
 Species Reactivity    Human
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 Specificity    This antibody was selected for its ability to detect human Kallikrenin-7.
 Purity/Purification    Protein G chromatography
 Form/Format    Lyophilized from a 0.2um filtered solution in phosphate-buffered saline (PBS).
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Kallikrein-7.
 Antigen    Recombinant human Kallikrein-7
 Buffer    PBS
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-KLK7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KLK7 antibody

   The human tissue kallikrein (KLK) gene family contains 15 members that play important roles in cancer. Notably, kallikrein-1, also known as tissue kallikrein, cleaves kininogen to release the vasoactive kinin peptide, bradykinin or lysyl-bradykinin. Kallikrein-3, called prostate specific antigen (PSA), is an established tumor marker that aids in the diagnosis, staging, and follow up of prostate cancer. Kallikrein-4 is specifically expressed in the prostate and over-expressed in prostate cancer. Kallikrein-5 is widely expressed but found at high levels in skin, breast, brain and testis; over-expression is an indicator of poor prognosis in ovarian cancer. Kallikrein-8 is expressed in the brain and is a novel marker of ovarian and cervical cancer.
 Applications Tested/Suitable for anti-KLK7 antibody   

Western Blot (WB), Neutralization of Kalikrein-7: Yes

 Application Notes for anti-KLK7 antibody    WB: Yes (1:500-1:1000)
Optimal dilutions should be determined by wach laboratory for each application.
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NCBI/Uniprot data below describe general gene information for KLK7. It may not necessarily be applicable to this product.
 NCBI GI #    333609286
 NCBI GeneID    5650
 NCBI Accession #    NP_001193982.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001207053.1 [Other Products]
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 UniProt Primary Accession #    P49862 [Other Products]
 UniProt Secondary Accession #    Q8N5N9; Q8NFV7; A8K0U5 [Other Products]
 UniProt Related Accession #    P49862 [Other Products]
 Molecular Weight    27,525 Da [Similar Products]
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 NCBI Official Full Name    kallikrein-7 isoform 2
 NCBI Official Synonym Full Names    kallikrein-related peptidase 7
 NCBI Official Symbol    KLK7 [Similar Products]
 NCBI Official Synonym Symbols   
hK7; SCCE; PRSS6
[Similar Products]
 NCBI Protein Information    kallikrein-7; signal protein; serine protease 6; stratum corneum chymotryptic enzyme; kallikrein 7 (chymotryptic, stratum corneum)
 UniProt Protein Name    Kallikrein-7
 UniProt Synonym Protein Names   
Serine protease 6; Stratum corneum chymotryptic enzyme
 Protein Family    Kallikrein
 UniProt Gene Name    KLK7 [Similar Products]
 UniProt Synonym Gene Names    PRSS6; SCCE; hK7; hSCCE [Similar Products]
 UniProt Entry Name    KLK7_HUMAN
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 NCBI Summary for KLK7    This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
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 UniProt Comments for KLK7    Function: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Ref.11

Catalytic activity: Cleavage of proteins with aromatic side chains in the P1 position.

Enzyme regulation: Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12. Ref.11

Subcellular location: Secreted. Note: In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front. Ref.5

Tissue specificity: Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). Ref.2 Ref.5

Induction: By estrogens and glucocorticoids in a breast carcinoma cell line. Ref.2 Ref.11

Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.
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 Research Articles on KLK7    1. KLK7 and KLK14 gene expression can be regarded as markers of poor prognosis for colorectal cancer patients with discriminating power between CC and adenoma patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KLK7 antibodyPathways associated with anti-KLK7 antibody
 Reference Product  PubMed Publications
 KLK5 antibody  >66 publications with KLK7 and KLK5
 KLK8 antibody  >26 publications with KLK7 and KLK8
 SPINK5 antibody  >21 publications with KLK7 and SPINK5
 KLK10 antibody  >13 publications with KLK7 and KLK10
 CDSN antibody  >8 publications with KLK7 and CDSN
 A2ML1 antibody  >2 publications with KLK7 and A2ML1
 Products by Pathway  Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with anti-KLK7 antibodyOrgans/Tissues associated with anti-KLK7 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >44 publications with KLK7 and Neoplasms
 Genital Neoplasms, Female Antibodies  >15 publications with KLK7 and Genital Neoplasms, Female
 Ovarian Neoplasms Antibodies  >14 publications with KLK7 and Ovarian Neoplasms
 Adenocarcinoma Antibodies  >13 publications with KLK7 and Adenocarcinoma
 Inflammation Antibodies  >13 publications with KLK7 and Inflammation
 Carcinoma, Squamous Cell Antibodies  >8 publications with KLK7 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >8 publications with KLK7 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with KLK7 and Neoplasms, Experimental
 Hyperplasia Antibodies  >4 publications with KLK7 and Hyperplasia
 Lung Diseases Antibodies  >4 publications with KLK7 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >100 publications with KLK7 and Skin
 Prostate Antibodies  >11 publications with KLK7 and Prostate
 Mouth Antibodies  >7 publications with KLK7 and Mouth
 Pancreas Antibodies  >7 publications with KLK7 and Pancreas
 Ovary Antibodies  >6 publications with KLK7 and Ovary
 Brain Antibodies  >6 publications with KLK7 and Brain
 Lung Antibodies  >4 publications with KLK7 and Lung
 Kidney Antibodies  >3 publications with KLK7 and Kidney
 Mammary Gland Antibodies  >3 publications with KLK7 and Mammary Gland
 Lymph Node Antibodies  >3 publications with KLK7 and Lymph Node
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