View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List anti-IGKC antibody :: Mouse anti-Human Kappa Light Chain Monoclonal Antibody Catalog # MBS301349 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Kappa Light Chain (IGKC), Monoclonal Antibody Full Product Name Mouse Anti-Human Kappa Light Chain Monoclonal Antibody (Clone SPM508) Product Gene Name anti-IGKC antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Monoclonal Isotype IgG1 Clone Number SPM508 Host Mouse Species Reactivity Human Form/Format 0.1 ml mouse monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide. Immunogen B-lymphoma cells. Control Tissue Tonsil Cellular Localization Cytoplasm Entrez Gene Code 3514 Pathway Hematopoiesis Preparation and Storage Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support. Other Notes Small volumes of anti-IGKC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-IGKC antibody Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit; while, IgM is a pentamer. IgA may also form polymers. Kappa light chain contains one immunoglobulin-like domain. Applications Tested/Suitable for anti-IGKC antibody Immunohistochemistry (IHC) Paraffin, Western Blot (WB) Application Notes for anti-IGKC antibody Immunohistochemistry ProcedureSpecimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:200. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.Immunohistochemistry Dilution: 1:200IHC Positive Control: TonsilWestern BlotRecommended Starting Protocol: Dilute the antibody 1:25. Incubate for 1 hour at room temperature. The dilution is an estimate; actual results may differ because of variability in methods and protocols. Optimal dilution and procedure should be determined by the end user.Western Blot Positive Control: Spleen Cell Lysate Western Blot (WB) of anti-IGKC antibody Western Blot analysis of spleen cell lysate with kappa light chain antibody Immunohistochemistry (IHC) of anti-IGKC antibody Human tonsil stained with anti-kappa light chain antibody TOP NCBI/Uniprot data below describe general gene information for IGKC. It may not necessarily be applicable to this product. NCBI GI # 125765 NCBI GeneID 3514 NCBI Accession # P01601.1 [Other Products] UniProt Related Accession # P01601; P01834; P04431[Other Products] Molecular Weight 25 kDa[Similar Products] TOP NCBI Official Full Name Ig kappa chain V-I region HK101 NCBI Official Synonym Full Names immunoglobulin kappa constant NCBI Official Symbol IGKC [Similar Products] NCBI Official Synonym Symbols Km; HCAK1; IGKCD [Similar Products] UniProt Protein Name Ig kappa chain V-I region HK101 UniProt Entry Name KV109_HUMAN TOP TOP UniProt Comments for IGKC KV109: Protein type: Immunoglobulin superfamilyChromosomal Location of Human Ortholog: 2p12Cellular Component: extracellular space; plasma membrane; extracellular regionMolecular Function: antigen bindingBiological Process: receptor-mediated endocytosis; retinal homeostasis; regulation of immune response; innate immune response; immune response; complement activation, classical pathway; complement activationDisease: Immunoglobulin Kappa Light Chain Deficiency Research Articles on IGKC 1. genetic polymorphism is associated with immunobiology of breast cancer in Japan TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Pathways associated with anti-IGKC antibody Products by Pathway Pathway Diagram Adaptive Immune System Pathway antibodies Adaptive Immune System Pathway Diagram Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram Classical Antibody-mediated Complement Activation Pathway antibodies Classical Antibody-mediated Complement Activation Pathway Diagram Complement Cascade Pathway antibodies Complement Cascade Pathway Diagram Creation Of C4 And C2 Activators Pathway antibodies Creation Of C4 And C2 Activators Pathway Diagram FCERI Mediated Ca+2 Mobilization Pathway antibodies FCERI Mediated Ca+2 Mobilization Pathway Diagram FCERI Mediated MAPK Activation Pathway antibodies FCERI Mediated MAPK Activation Pathway Diagram FCERI Mediated NF-kB Activation Pathway antibodies FCERI Mediated NF-kB Activation Pathway Diagram FCGR Activation Pathway antibodies FCGR Activation Pathway Diagram Organs/Tissues associated with anti-IGKC antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >7 publications with IGKC and Blood Lung Antibodies >7 publications with IGKC and Lung Muscle Antibodies >2 publications with IGKC and Muscle Vascular Antibodies >2 publications with IGKC and Vascular Eye Antibodies >2 publications with IGKC and Eye Uncharacterized Tissue Antibodies >2 publications with IGKC and Uncharacterized Tissue Skin Antibodies >1 publications with IGKC and Skin TOP © 2006-24 MyBioSource.com. 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