BAA24840.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
keratan sulfate Gal-6-sulfotransferase
NCBI Official Synonym Full Names
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
NCBI Official Synonym Symbols
C6ST; KSST; GST-1; KS6ST; KSGal6ST [Similar Products]
NCBI Protein Information
carbohydrate sulfotransferase 1; carbohydrate (chondroitin 6/keratan) sulfotransferase 1; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1
UniProt Protein Name
Carbohydrate sulfotransferase 1
UniProt Synonym Protein Names
Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; GST-1; Keratan sulfate Gal-6 sulfotransferase
UniProt Synonym Gene Names
UniProt Entry Name
CHST1_HUMAN
NCBI Summary for CHST1
This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]
UniProt Comments for CHST1
CHST1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Protein type: Transferase; Glycan Metabolism - keratan sulfate biosynthesis; EC 2.8.2.21; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: sulfotransferase activity; keratan sulfotransferase activity
Biological Process: keratan sulfate metabolic process; sulfur metabolic process; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; carbohydrate metabolic process; galactose metabolic process; polysaccharide metabolic process; pathogenesis; inflammatory response
Research Articles on CHST1
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Products associated with anti-CHST1 antibody
Pathways associated with anti-CHST1 antibody
Diseases associated with anti-CHST1 antibody
Organs/Tissues associated with anti-CHST1 antibody
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