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anti-KRT17 antibody :: Mouse anti-Human Keratin 17 (KRT17) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2090671
Western Blot (WB)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $145 +1 FREE 8GB USB
0.1 mg  /  $175 +1 FREE 8GB USB
0.2 mg  /  $230 +1 FREE 8GB USB
1 mg  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Keratin 17 (KRT17), Monoclonal Antibody

 Also Known As   

Monoclonal Antibody to Keratin 17 (KRT17)

 Product Synonym Names    PC2; CK17; K17; PC; PCHC1; Cytokeratin 17; Keratin, type I cytoskeletal 17
 Product Gene Name   

anti-KRT17 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    Z19574 Genomic DNA
 3D Structure    ModBase 3D Structure for Q04695
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 Clonality    Monoclonal
 Isotype    IgG2a Kappa
 Clone Number    C11
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against KRT17. It has been selected for its ability to recognize KRT17 in immunohistochemical staining and western blotting.
 Purity/Purification    Protein A + Protein G affinity chromatography
 Form/Format    Liquid
 Concentration    1mg/mL (lot specific)
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 Immunogen    Recombinant Keratin 17 (KRT17)
 Buffer Formulation    PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-KRT17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KRT17 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

 Application Notes for anti-KRT17 antibody    Western blotting: 0.2-2ug/mL;1:500-5000
Immunohistochemistry: 5-20ug/mL;1:50-200
Immunocytochemistry: 5-20ug/mL;1:50-200
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-KRT17 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-KRT17 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for KRT17. It may not necessarily be applicable to this product.
 NCBI GI #    4557701
 NCBI GeneID    3872
 NCBI Accession #    NP_000413.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000422.2 [Other Products]
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 UniProt Primary Accession #    Q04695 [Other Products]
 UniProt Secondary Accession #    Q6IP98; Q8N1P6; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2 [Other Products]
 UniProt Related Accession #    Q04695 [Other Products]
 Molecular Weight    48,106 Da
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 NCBI Official Full Name    keratin, type I cytoskeletal 17
 NCBI Official Synonym Full Names    keratin 17
 NCBI Official Symbol    KRT17 [Similar Products]
 NCBI Official Synonym Symbols   
PC; K17; PC2; 39.1; CK-17; PCHC1
[Similar Products]
 NCBI Protein Information    keratin, type I cytoskeletal 17
 UniProt Protein Name    Keratin, type I cytoskeletal 17
 UniProt Synonym Protein Names   
39.1; Cytokeratin-17; CK-17; Keratin-17; K17
 Protein Family    Keratin
 UniProt Gene Name    KRT17 [Similar Products]
 UniProt Synonym Gene Names    CK-17; K17 [Similar Products]
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 NCBI Summary for KRT17    This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
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 UniProt Comments for KRT17    K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cell periphery; cytosol; extracellular exosome; intermediate filament; intermediate filament cytoskeleton

Molecular Function: MHC class II protein binding; MHC class II receptor activity; protein binding; structural constituent of cytoskeleton

Biological Process: cornification; epidermis development; hair follicle morphogenesis; intermediate filament organization; keratinization; positive regulation of cell growth; positive regulation of hair follicle development; positive regulation of translation; signal transduction

Disease: Pachyonychia Congenita 2; Steatocystoma Multiplex
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 Research Articles on KRT17    1. Krt17 was demonstrated to contribute to areca nut-induced oral malignancy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KRT17 antibodyPathways associated with anti-KRT17 antibody
 Reference Product  PubMed Publications
 KRT6A antibody  >17 publications with KRT17 and KRT6A
 KRT7 antibody  >1 publications with KRT17 and KRT7
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
Diseases associated with anti-KRT17 antibodyOrgans/Tissues associated with anti-KRT17 antibody
 Disease Name  Pubmed Publications
 Pachyonychia congenita Jackson Lawler type Antibodies  >20 publications with KRT17 and Pachyonychia congenita Jackson Lawler type
 Neoplasms Antibodies  >19 publications with KRT17 and Neoplasms
 Adenocarcinoma Antibodies  >7 publications with KRT17 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >7 publications with KRT17 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >5 publications with KRT17 and Breast Neoplasms
 Pain Antibodies  >4 publications with KRT17 and Pain
 Skin Neoplasms Antibodies  >3 publications with KRT17 and Skin Neoplasms
 Carcinoma, Basal Cell Antibodies  >2 publications with KRT17 and Carcinoma, Basal Cell
 Esophageal Squamous Cell Carcinoma Antibodies  >2 publications with KRT17 and Esophageal Squamous Cell Carcinoma
 Precancerous Conditions Antibodies  >1 publications with KRT17 and Precancerous Conditions
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >16 publications with KRT17 and Skin
 Mouth Antibodies  >3 publications with KRT17 and Mouth
 Lymph Antibodies  >2 publications with KRT17 and Lymph
 Mammary Gland Antibodies  >2 publications with KRT17 and Mammary Gland
 Lymph Node Antibodies  >2 publications with KRT17 and Lymph Node
 Intestine Antibodies  >1 publications with KRT17 and Intestine
 Bladder Antibodies  >1 publications with KRT17 and Bladder
 Prostate Antibodies  >1 publications with KRT17 and Prostate
 Muscle Antibodies  >1 publications with KRT17 and Muscle
 Pancreas Antibodies  >1 publications with KRT17 and Pancreas
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