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anti-KRT10 antibody :: Mouse Keratin K10 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531604 anti-KRT10 antibody
Unit / Price
1 mL  /  $490 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Keratin K10 (KRT10), Monoclonal Antibody

 Also Known As   

Keratin K10 antibody

 Product Synonym Names    Monoclonal Keratin K10; Anti-Keratin K10; Keratin K 10; Keratin K-10; Keratin K10; Cytokeratin 10
 Product Gene Name   

anti-KRT10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    113800
 3D Structure    ModBase 3D Structure for P13645
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    DE-K10
 Host    Mouse
 Species Reactivity    Human keratin K10
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 Purity/Purification    Culture supernatant
 Form/Format    Suppleid as culture supernatant diluted in 0.15 M PBS with 1% BSA and 0.1% NaN3
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 Biological Significance    Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Keratin K10 antibody was raised in mouse using cytoskeletal preparation from human epidermis as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-KRT10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KRT10 antibody

   Mouse monoclonal Keratin K10 antibody
 Product Categories/Family for anti-KRT10 antibody    Cell Biology
 Applications Tested/Suitable for anti-KRT10 antibody   

Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)

 Application Notes for anti-KRT10 antibody    IHC-F: 1:5-1:10
IHC-P: 1:5-1:10
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NCBI/Uniprot data below describe general gene information for KRT10. It may not necessarily be applicable to this product.
 NCBI GI #    195972866
 NCBI GeneID    3858
 NCBI Accession #    NP_000412.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000421.3 [Other Products]
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 UniProt Primary Accession #    P13645 [Other Products]
 UniProt Secondary Accession #    Q14664; Q8N175 [Other Products]
 UniProt Related Accession #    P13645 [Other Products]
 Molecular Weight    58,827 Da [Similar Products]
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 NCBI Official Full Name    keratin, type I cytoskeletal 10
 NCBI Official Synonym Full Names    keratin 10, type I
 NCBI Official Symbol    KRT10 [Similar Products]
 NCBI Official Synonym Symbols   
BIE; EHK; K10; KPP; BCIE; CK10
[Similar Products]
 NCBI Protein Information    keratin, type I cytoskeletal 10
 UniProt Protein Name    Keratin, type I cytoskeletal 10
 UniProt Synonym Protein Names   
Cytokeratin-10; CK-10; Keratin-10; K10
 Protein Family    Keratin
 UniProt Gene Name    KRT10 [Similar Products]
 UniProt Synonym Gene Names    KPP; CK-10; K10 [Similar Products]
 UniProt Entry Name    K1C10_HUMAN
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 NCBI Summary for KRT10    This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KRT10    K10: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K1.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extracellular space; membrane; keratin filament; cytoplasm; intermediate filament; nucleus

Molecular Function: structural constituent of epidermis

Biological Process: keratinocyte differentiation

Disease: Erythroderma, Ichthyosiform, Congenital Reticular; Epidermolytic Hyperkeratosis; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis
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 Research Articles on KRT10    1. We present the spectrum of clinical variability of ichthyosis with confetti in 6 patients with confirmed mutations in KRT10.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KRT10 antibodyPathways associated with anti-KRT10 antibody
 Reference Product  PubMed Publications
 KRT1 antibody  >55 publications with KRT10 and KRT1
 KRT2 antibody  >6 publications with KRT10 and KRT2
 CCND1 antibody  >4 publications with KRT10 and CCND1
 Products by Pathway  Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
Diseases associated with anti-KRT10 antibodyOrgans/Tissues associated with anti-KRT10 antibody
 Disease Name  Pubmed Publications
 Hyperkeratosis, Epidermolytic Antibodies  >44 publications with KRT10 and Hyperkeratosis, Epidermolytic
 Carcinoma, Squamous Cell Antibodies  >18 publications with KRT10 and Carcinoma, Squamous Cell
 Inflammation Antibodies  >10 publications with KRT10 and Inflammation
 Skin Neoplasms Antibodies  >10 publications with KRT10 and Skin Neoplasms
 Necrosis Antibodies  >6 publications with KRT10 and Necrosis
 Breast Neoplasms Antibodies  >5 publications with KRT10 and Breast Neoplasms
 Lung Neoplasms Antibodies  >4 publications with KRT10 and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >4 publications with KRT10 and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >4 publications with KRT10 and Ovarian Diseases
 Hyperplasia Antibodies  >3 publications with KRT10 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >111 publications with KRT10 and Skin
 Mouth Antibodies  >12 publications with KRT10 and Mouth
 Lung Antibodies  >6 publications with KRT10 and Lung
 Esophagus Antibodies  >2 publications with KRT10 and Esophagus
 Embryonic Tissue Antibodies  >2 publications with KRT10 and Embryonic Tissue
 Ovary Antibodies  >2 publications with KRT10 and Ovary
 Vascular Antibodies  >2 publications with KRT10 and Vascular
 Cervix Antibodies  >1 publications with KRT10 and Cervix
 Eye Antibodies  >1 publications with KRT10 and Eye
 Brain Antibodies  >1 publications with KRT10 and Brain
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