NP_940927.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
150,587 Da
NCBI Official Full Name
kinesin-like protein KIF7
NCBI Official Synonym Full Names
kinesin family member 7
NCBI Official Synonym Symbols
ACLS; AGBK; HLS2; JBTS12; UNQ340 [Similar Products]
NCBI Protein Information
kinesin-like protein KIF7
UniProt Protein Name
Kinesin-like protein KIF7
NCBI Summary for Kif 7
This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011]
UniProt Comments for Kif 7
Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (). Involved in the regulation of epidermal differentiation and chondrocyte development ().
Research Articles on Kif 7
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Diseases associated with anti-Kif 7 antibody
Organs/Tissues associated with anti-Kif 7 antibody
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