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anti-XRCC6 (p70) antibody :: Mouse Ku (p70/p80) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS438044 anti-XRCC6 (p70) antibody
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ku (p70/p80) (XRCC6 (p70)), Monoclonal Antibody

★Popular Item★
 Also Known As   

Ku (p70/p80)

 Product Synonym Names    Ku (p70): 70 kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22P1; Ku autoantigen; 70kDa; Ku70; Kup70; Lupus Ku autoantigen protein p70; ML8; Thyroid autoantigen 70kD (Ku antigen); Thyroid-lupus autoantigen (TLAA); X-ray repair cross-complementing protein 6 (XRCC6) Ku (p80): 86kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 2; ATP dependent DNA helicase II 86 Kd subunit; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; KARP1; Ku autoantigen 80kDa; Ku80; Ku86 autoantigen related protein 1; KUB2; Lupus Ku autoantigen protein p86; Nuclear factor IV (NFIV); Thyroid-lupus autoantigen (TLAA); X-ray repair cross-complementing protein 5 (XRCC5)
 Product Gene Name   

anti-XRCC6 (p70) antibody

[Similar Products]
 Product Synonym Gene Name    XRCC5 (p80) [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    152690
 3D Structure    ModBase 3D Structure for P12956
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    KU729
 Host    Mouse
 Species Reactivity    Human, Primates. Does not react with mouse, rat and chicken.
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 Specificity    Recognizes a dimer of two proteins of 70kDa and ~80kDa, identified as two subunits of Ku. MAb KU729 recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
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 Localization    Nuclear
 Positive Control    Human cancer K562, HL-60, HEp-2 or HeLa cells
 Human Chromosomal Location    XRCC6 (p70); XRCC5 (p80)
 Immunogen    Nuclear extract of human HL-60 cells
 Quantity and Buffer    0.5 ml at 200ug/ml with BSA and azide
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 Preparation and Storage    Store at 2 to 8 degree C. Antibody is stable for 24 months.
 Other Notes    Small volumes of anti-XRCC6 (p70) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-XRCC6 (p70) antibody   

Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistology (IH)

 Application Notes for anti-XRCC6 (p70) antibody    Immunofluorescence (0.5-1.0ug/ml); Immunoprecipitation (0.5-1ug/500ug protein lysate); Immunocytochemistry (Acetone-fixed cells) (0.25-0.5ug/ml for 30 minutes at RT) Immunohistology (Frozen & Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
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NCBI/Uniprot data below describe general gene information for XRCC6 (p70). It may not necessarily be applicable to this product.
 NCBI GI #    573014815
 NCBI GeneID    2547
 NCBI Accession #    NP_001275905.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288976.1 [Other Products]
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 UniProt Primary Accession #    P12956 [Other Products]
 UniProt Secondary Accession #    Q6FG89; Q9UCQ2; Q9UCQ3; B1AHC8 [Other Products]
 UniProt Related Accession #    P12956 [Other Products]
 Molecular Weight    70kDa; 80kDa
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 NCBI Official Full Name    X-ray repair cross-complementing protein 6 isoform 1
 NCBI Official Synonym Full Names    X-ray repair complementing defective repair in Chinese hamster cells 6
 NCBI Official Symbol    XRCC6 [Similar Products]
 NCBI Official Synonym Symbols   
ML8; KU70; TLAA; CTC75; CTCBF; G22P1
[Similar Products]
 NCBI Protein Information    X-ray repair cross-complementing protein 6; 5'-dRP lyase Ku70; Ku autoantigen, 70kDa; DNA repair protein XRCC6; Ku autoantigen p70 subunit; 70 kDa subunit of Ku antigen; thyroid-lupus autoantigen p70; lupus Ku autoantigen protein p70; 5'-deoxyribose-5-phosphate lyase Ku70; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; thyroid autoantigen 70kD (Ku antigen); ATP-dependent DNA helicase 2 subunit 1; thyroid autoantigen 70kDa (Ku antigen); ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit
 UniProt Protein Name    X-ray repair cross-complementing protein 6
 UniProt Synonym Protein Names   
5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6
 UniProt Gene Name    XRCC6 [Similar Products]
 UniProt Synonym Gene Names    G22P1; 5'-dRP lyase Ku70; CTC75; CTCBF; Ku70; TLAA [Similar Products]
 UniProt Entry Name    XRCC6_HUMAN
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 NCBI Summary for XRCC6 (p70)    The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
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 UniProt Comments for XRCC6 (p70)    Ku70: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

Protein type: Nuclear receptor co-regulator; DNA repair, damage; RNA-binding; DNA-binding; EC 4.2.99.-; Helicase; EC 3.6.4.-

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; transcription factor complex; nuclear telomere cap complex; membrane; nucleolus; nucleus; cytosol

Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; DNA binding; double-stranded DNA binding; damaged DNA binding; double-stranded telomeric DNA binding; 5'-deoxyribose-5-phosphate lyase activity; ATP binding

Biological Process: positive regulation of neurogenesis; V(D)J recombination; transcription, DNA-dependent; viral reproduction; positive regulation of transcription, DNA-dependent; DNA repair; DNA duplex unwinding; double-strand break repair via nonhomologous end joining; DNA ligation; double-strand break repair; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; telomere maintenance
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 Research Articles on XRCC6 (p70)    1. SET/TAF-Ibeta interacts with Ku70/80 in the nucleus and inhibits Ku70 acetylation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-XRCC6 (p70) antibodyPathways associated with anti-XRCC6 (p70) antibody
 Reference Product  PubMed Publications
 XRCC5 antibody  >21 publications with XRCC6 (p70) and XRCC5
 XRCC4 antibody  >9 publications with XRCC6 (p70) and XRCC4
 LIG4 antibody  >5 publications with XRCC6 (p70) and LIG4
 PARP1 antibody  >3 publications with XRCC6 (p70) and PARP1
 PRKDC antibody  >3 publications with XRCC6 (p70) and PRKDC
 TP53 antibody  >1 publications with XRCC6 (p70) and TP53
 SIRT1 antibody  >1 publications with XRCC6 (p70) and SIRT1
 BAX antibody  >1 publications with XRCC6 (p70) and BAX
 WRN antibody  >1 publications with XRCC6 (p70) and WRN
 Products by Pathway  Pathway Diagram
 2-LTR Circle Formation Pathway antibodies  2-LTR Circle Formation Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
Diseases associated with anti-XRCC6 (p70) antibodyOrgans/Tissues associated with anti-XRCC6 (p70) antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >12 publications with XRCC6 (p70) and Carcinoma
 Adenocarcinoma Antibodies  >9 publications with XRCC6 (p70) and Adenocarcinoma
 Breast Neoplasms Antibodies  >5 publications with XRCC6 (p70) and Breast Neoplasms
 Liver Neoplasms Antibodies  >4 publications with XRCC6 (p70) and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with XRCC6 (p70) and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >4 publications with XRCC6 (p70) and Liver Diseases
 Lymphoma Antibodies  >4 publications with XRCC6 (p70) and Lymphoma
 Chromosome Aberrations Antibodies  >3 publications with XRCC6 (p70) and Chromosome Aberrations
 Lung Neoplasms Antibodies  >3 publications with XRCC6 (p70) and Lung Neoplasms
 Ovarian Diseases Antibodies  >2 publications with XRCC6 (p70) and Ovarian Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with XRCC6 (p70) and Blood
 Liver Antibodies  >5 publications with XRCC6 (p70) and Liver
 Lung Antibodies  >4 publications with XRCC6 (p70) and Lung
 Kidney Antibodies  >3 publications with XRCC6 (p70) and Kidney
 Brain Antibodies  >3 publications with XRCC6 (p70) and Brain
 Bone Antibodies  >2 publications with XRCC6 (p70) and Bone
 Bladder Antibodies  >2 publications with XRCC6 (p70) and Bladder
 Bone Marrow Antibodies  >2 publications with XRCC6 (p70) and Bone Marrow
 Testis Antibodies  >2 publications with XRCC6 (p70) and Testis
 Prostate Antibodies  >2 publications with XRCC6 (p70) and Prostate
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