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anti-Kv3.2 antibody :: Mouse Kv3.2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS806992
Western Blot (WB)
Unit / Price
0.1 mg  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kv3.2, Monoclonal Antibody

 Also Known As   

Mouse Anti-Rat Kv3.2 Monoclonal IgG1

 Product Synonym Names    Potassium voltage-gated channel subfamily C member 2 Antibody; Kcnc2 Antibody; KSHIIIA Antibody; Kv3.2 Antibody: ATTO 633; Mouse Anti-Rat Kv3.2 Monoclonal, Clone S410-17; Anti-Kv3.2; Kv3.2 Antibody
 Product Gene Name   

anti-Kv3.2 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Kv3.2 Clone #S410-17 (MBS807005)
ATTO 633 Conjugated Antibody: Kv3.2 Clone #S410-17 (MBS806992)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P22462
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    S410-17
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Protein G Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Fusion protein amino acids 474-613 (Cytoplasmic C-terminus) of rat Kv3.2a
 Immunogen Species    Rat
 COA    A 1:100 dilution was sufficient for detection of Kv3.2 in 20 ug of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
 Storage Buffer    PBS pH7.4, 50% glycerol, 0.1% sodium azide
 Conjugate    ATTO 633
 Cellular Localization    Cell Membrane
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-Kv3.2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Kv3.2 antibody

   Kv3.2, a member of the KCNC2 gene family, belongs to a group of potassium channels that contribute to the maintenance of cell volume, membrane potential, neuronal excitability and the secretion of transmitters, salt and hormones. Kv3.2 are predominantly expressed in neurons that fire at high frequencies, and in the fast spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus (1-3). They specifically functioning as a delayed rectifier activated by large membrane depolarizations (2, 4).
 Product Categories/Family for anti-Kv3.2 antibody    Neuroscience; Ion channels; Potassium Channels; Voltage-Gated Potassium Channels
 Applications Tested/Suitable for anti-Kv3.2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-Kv3.2 antibody    Western Blot: 1:1000
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 Western Blot (WB) of anti-Kv3.2 antibody    Western Blot analysis of Mouse, Rat Brain showing detection of ~80-100 kDa Kv3.2 protein using Mouse Anti-Kv3.2 Monoclonal Antibody, Clone S410-17. Lane 1: MW Ladder. Lane 2: Mouse Brain. Lane 3: Rat Brain Membrane. Lane 4: Rat Brain. Load: 20 ug. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Kv3.2 Monoclonal Antibody at 1:1000 for 16 hours at 4 degree C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~80-100 kDa. Other Band(s): ~30 kDa for Rat Brain .
anti-Kv3.2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Kv3.2. It may not necessarily be applicable to this product.
 NCBI GI #    41281706
 NCBI GeneID    246153
 NCBI Accession #    NP_631962.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_139216.1 [Other Products]
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 UniProt Primary Accession #    P22462 [Other Products]
 UniProt Secondary Accession #    P22461; P22463; Q63735 [Other Products]
 UniProt Related Accession #    P22462 [Other Products]
 Molecular Weight    Detects ~80-100kDa.
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 NCBI Official Full Name    potassium voltage-gated channel subfamily C member 2 isoform a
 NCBI Official Synonym Full Names    potassium voltage-gated channel subfamily C member 2
 NCBI Official Symbol    Kcnc2 [Similar Products]
 NCBI Official Synonym Symbols   
Kv3.2; KShIIIA
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily C member 2
 UniProt Protein Name    Potassium voltage-gated channel subfamily C member 2
 UniProt Synonym Protein Names   
Potassium channel voltage-gated Shaw-related subfamily C member 2
 UniProt Gene Name    Kcnc2 [Similar Products]
 UniProt Entry Name    KCNC2_RAT
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 NCBI Summary for Kv3.2    a voltage-gated K+ channel; functions as a delayed rectifier-type K+ channel activated by large membrane depolarizations [RGD, Feb 2006]
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 UniProt Comments for Kv3.2    KCNC2: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system (PubMed:10482766, PubMed:10414968, PubMed:11506885, PubMed:22831914). Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly (PubMed:2367536, PubMed:1879548, PubMed:8120636, PubMed:7643197, PubMed:10414303). Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2367536, PubMed:1879548, PubMed:8120636, PubMed:7643197). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10482766, PubMed:14679187). Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 and KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (PubMed:11281123, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:10482766, PubMed:10414968, PubMed:11506885, PubMed:22831914). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity)

Protein type: Membrane protein, multi-pass; Membrane protein, integral
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Product References and Citations for anti-Kv3.2 antibody

   1. Kolodin Y.O. (2008) http://ykolodin.50webs.com/ 2. Rudy B., McBain C.J. (2001) Trends Neurosci. 24(9): 517-526. 3. Gutman G.A., et al. (2005) Pharmacol Rev. 57(4): 472-508. 4. Rudy B, et al. (1999) Ann. NY Acad. Sci. 868: 304-343.
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 Research Articles on Kv3.2    1. In the absence of potassium ion, significant N-methyl-D-glucamine (NMDG)-positive currents could be recorded from human embryonic kidney cells expressing Kv3.1 or Kv3.2b channels and Kv1.5 Arg487Tyr/Val, but not wild-type channels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Kv3.2 antibodyDiseases associated with anti-Kv3.2 antibody
 Products by Pathway  Pathway Diagram
 Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway antibodies  Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >4 publications with Kv3.2 and Brain Diseases
 Neurodegenerative Diseases Antibodies  >2 publications with Kv3.2 and Neurodegenerative Diseases
 Disease Models, Animal Antibodies  >2 publications with Kv3.2 and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >1 publications with Kv3.2 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >1 publications with Kv3.2 and Learning Disorders
Organs/Tissues associated with anti-Kv3.2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with Kv3.2 and Brain
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