AAC53390.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
l-Afadin
NCBI Official Synonym Full Names
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NCBI Official Synonym Symbols
NCBI Protein Information
afadin; protein Af-6; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog
UniProt Protein Name
Afadin
UniProt Synonym Protein Names
Protein Af-6
UniProt Synonym Gene Names
UniProt Entry Name
AFAD_RAT
NCBI Summary for Mllt4
may play a role in linking the actin cytoskeleton to the plasma membrane [RGD, Feb 2006]
UniProt Comments for Mllt4
Afadin: plays a role in adhesion by participating, along with E-cadherin and catenin, in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Essential for the association of nectin and E-cadherin. Contains 1 forkhead-associated (FHA) domain, a phosphopeptide recognition domain; 1 dilute (DIL) domain, a myosin-like domain which may play a functional role in cellular processes or vectorial vesicle transport; 1 PDZ domain, which frequently binds the carboxyl-terminal sequences of proteins or phosphatidylinositol 4,5-bisphosphate in the plasma membrane; and 2 RA domains, which are associated with RasGTP effector activity. Five alternatively spliced isoforms have been described. Isoform 2 does not interact with F-actin.
Protein type: Oncoprotein; Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: nucleoplasm; adherens junction; cell-cell adherens junction; apical part of cell; cytoplasm; plasma membrane; intercellular junction; nucleus; cytosol; cell junction
Molecular Function: protein binding; LIM domain binding; Ras GTPase binding; cell adhesion molecule binding
Biological Process: cell adhesion; signal transduction
Product References and Citations for anti-Mllt4 antibody
1. Sakisaka, T et al; Different behavior of l-afadin and neurabin-II during the formation and destruction of cell-cell adherens junction. Oncogene 1999, 18: 1609 2. Takahashi, K et al; Nectin/PRR: An immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with afadin, a PDZ domain-containing protein. J Cell Biol 1999, 145: 539
Research Articles on Mllt4
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Products associated with anti-Mllt4 antibody
Pathways associated with anti-Mllt4 antibody
Diseases associated with anti-Mllt4 antibody
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