AGE97055.1
[Other Products]
Molecular Weight
15,102 Da
NCBI Official Full Name
L1 protein, partial
UniProt Protein Name
Major capsid protein L1
UniProt Entry Name
M1KNA9_HPV16
UniProt Comments for HPV
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
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