NP_068352
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
23,049 Da
NCBI Official Full Name
leukocyte-associated immunoglobulin-like receptor 1 isoform b
NCBI Official Synonym Full Names
leukocyte associated immunoglobulin like receptor 1
NCBI Protein Information
leukocyte-associated immunoglobulin-like receptor 1
UniProt Protein Name
Leukocyte-associated immunoglobulin-like receptor 1
UniProt Synonym Protein Names
CD_antigen: CD305
UniProt Synonym Gene Names
NCBI Summary for LAIR-1
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Comments for LAIR-1
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Product References and Citations for anti-LAIR-1 antibody
Meyaard L, et al., (1997) Immunity 7: 283-290.; Meyaard L, et al., (1999) J. Immunol 162: 5800-5804.
Research Articles on LAIR-1
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Products associated with anti-LAIR-1 antibody
Pathways associated with anti-LAIR-1 antibody
Diseases associated with anti-LAIR-1 antibody
Organs/Tissues associated with anti-LAIR-1 antibody
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