NP_005551.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,287 Da
NCBI Official Full Name
laminin subunit alpha-5
NCBI Official Synonym Full Names
laminin, alpha 5
NCBI Protein Information
laminin subunit alpha-5; laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha
UniProt Protein Name
Laminin subunit alpha-5
UniProt Synonym Protein Names
Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha
UniProt Synonym Gene Names
UniProt Entry Name
LAMA5_HUMAN
NCBI Summary for LAMININ ALPHA 5
This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]
UniProt Comments for LAMININ ALPHA 5
LAMA5: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Protein type: Secreted, signal peptide; Secreted; Extracellular matrix; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20q13.2-q13.3
Cellular Component: extracellular matrix; extracellular space; laminin-5 complex; laminin-1 complex; laminin-10 complex; extracellular region; basement membrane; basal lamina; nucleus
Molecular Function: integrin binding; structural molecule activity
Biological Process: integrin-mediated signaling pathway; focal adhesion formation; regulation of cell adhesion; endothelial cell differentiation; muscle development; extracellular matrix organization and biogenesis; cell migration; regulation of embryonic development; cytoskeleton organization and biogenesis; cell recognition; regulation of cell migration; regulation of cell proliferation; odontogenesis of dentine-containing teeth; extracellular matrix disassembly; cell proliferation; embryonic development; morphogenesis of embryonic epithelium; hair follicle development; ureteric bud branching; cilium biogenesis; angiogenesis; cell differentiation; neural crest cell migration; morphogenesis of a polarized epithelium; lung development
Research Articles on LAMININ ALPHA 5
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Products associated with anti-LAMININ ALPHA 5 antibody
Pathways associated with anti-LAMININ ALPHA 5 antibody
Diseases associated with anti-LAMININ ALPHA 5 antibody
Organs/Tissues associated with anti-LAMININ ALPHA 5 antibody
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