NP_001264155.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
leucine-rich repeat-containing G-protein coupled receptor 5 isoform 2
NCBI Official Synonym Full Names
leucine-rich repeat containing G protein-coupled receptor 5
NCBI Protein Information
leucine-rich repeat-containing G-protein coupled receptor 5
UniProt Protein Name
Leucine-rich repeat-containing G-protein coupled receptor 5
UniProt Synonym Protein Names
G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
UniProt Synonym Gene Names
UniProt Entry Name
LGR5_HUMAN
NCBI Summary for LGR5
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
UniProt Comments for LGR5
LGR5: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q22-q23
Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane
Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; inner ear development
Product References and Citations for anti-LGR5 antibody
Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010) Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010) Uchida, H., et al. Cancer Sci. 101(7):1731-1737(2010) Fan, X.S., et al. Int J Colorectal Dis 25(5):583-590(2010) Acevedo, A.C., et al. J. Dent. Res. 89(2):128-132(2010)
Research Articles on LGR5
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Products associated with anti-LGR5 antibody
Diseases associated with anti-LGR5 antibody
Organs/Tissues associated with anti-LGR5 antibody
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