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anti-LITAF antibody :: Mouse anti-Human LITAF Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200149
Western Blot (WB)
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LITAF, Monoclonal Antibody

 Also Known As   

LITAF antibody

 Product Synonym Names    lipopolysaccharide-induced TNF factor; PIG7; SIMPLE; FLJ38636; TP53I7
 Product Gene Name   

anti-LITAF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF010312 mRNA
 3D Structure    ModBase 3D Structure for Q99732
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 Clonality    Monoclonal
 Isotype    IgG2b, k
 Clone Number    AT1F9
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human LITAF (1-161aa) purified from E. coli
 Clone Note    Anti-human LITAF mAb, clone AT5C10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human LITAF protein.
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 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-LITAF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LITAF antibody

   Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) mediates the expression of inflammatory cytokines such as TNF-alpha in Lipopolysaccharide-induced processes. LITAF binds to STAT6B, a member of the STAT6 family forming a complex on the TNF-alpha promoter that modulates TNF activity. High levels of expression of LITAF mRNA have been observed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.
 Product Categories/Family for anti-LITAF antibody    Transcription & Translation
 Applications Tested/Suitable for anti-LITAF antibody   

ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-LITAF antibody    WB: 1:2000 ~ 3000.
Recommended starting dilution is 1:2000.
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 Western Blot (WB) of anti-LITAF antibody    The recombinant human LITAF protein (50ng) and Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human LITAF antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Recombinant protein Lane 2.: HeLa cell lysate Lane 3.: HepG2 cell lysate Lane 4.: A431 cell lysate Lane 5.: SW480 cell lysate
anti-LITAF antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for LITAF. It may not necessarily be applicable to this product.
 NCBI GI #    65787265
 NCBI GeneID    9516
 NCBI Accession #    NP_004853 [Other Products]
 NCBI GenBank Nucleotide #    NM_004862.3 [Other Products]
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 UniProt Primary Accession #    Q99732 [Other Products]
 UniProt Secondary Accession #    Q05DW0; Q9C0L6; D3DUG1; G5E9K0 [Other Products]
 UniProt Related Accession #    Q99732 [Other Products]
 Molecular Weight    15,824 Da
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 NCBI Official Full Name    lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1
 NCBI Official Synonym Full Names    lipopolysaccharide induced TNF factor
 NCBI Official Symbol    LITAF [Similar Products]
 NCBI Official Synonym Symbols   
PIG7; SIMPLE; TP53I7
[Similar Products]
 NCBI Protein Information    lipopolysaccharide-induced tumor necrosis factor-alpha factor
 UniProt Protein Name    Lipopolysaccharide-induced tumor necrosis factor-alpha factor
 UniProt Synonym Protein Names   
Small integral membrane protein of lysosome/late endosome
 Protein Family    Lipopolysaccharide-induced tumor necrosis factor-alpha factor
 UniProt Gene Name    LITAF [Similar Products]
 UniProt Synonym Gene Names    ; LPS-induced TNF-alpha factor [Similar Products]
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 NCBI Summary for LITAF    Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
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 UniProt Comments for LITAF    Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005).
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Product References and Citations for anti-LITAF antibody

   Atucchi A, et al., (2006) Inflamm Bowel Dis 13 (1):120-121; Tang X, et al., (2005) Proc Natl Acad Sci USA 102 (14):5132-5137; Tang X, et al., (2003) Proc Natl Acad Sci USA 100 (7):4096-4101
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 Research Articles on LITAF    1. Molecular analysis of Charcot-Marie-Tooth 1C revealed five new LITAF/SIMPLE mutations
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LITAF antibodyPathways associated with anti-LITAF antibody
 Reference Product  PubMed Publications
 LARGE antibody  >12 publications with LITAF and LARGE
 IMPACT antibody  >5 publications with LITAF and IMPACT
 STAT6 antibody  >5 publications with LITAF and STAT6
 NEDD4 antibody  >3 publications with LITAF and NEDD4
 TP53 antibody  >2 publications with LITAF and TP53
 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
Diseases associated with anti-LITAF antibodyOrgans/Tissues associated with anti-LITAF antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >90 publications with LITAF and Necrosis
 Inflammation Antibodies  >32 publications with LITAF and Inflammation
 Charcot-Marie-Tooth disease, Type 1C Antibodies  >11 publications with LITAF and Charcot-Marie-Tooth disease, Type 1C
 Liver Diseases Antibodies  >8 publications with LITAF and Liver Diseases
 Hyperplasia Antibodies  >3 publications with LITAF and Hyperplasia
 Weight Gain Antibodies  >3 publications with LITAF and Weight Gain
 Fatty Liver Antibodies  >2 publications with LITAF and Fatty Liver
 Kidney Diseases Antibodies  >2 publications with LITAF and Kidney Diseases
 Heart Diseases Antibodies  >2 publications with LITAF and Heart Diseases
 Insulin Resistance Antibodies  >2 publications with LITAF and Insulin Resistance
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >37 publications with LITAF and Blood
 Nerve Antibodies  >26 publications with LITAF and Nerve
 Intestine Antibodies  >22 publications with LITAF and Intestine
 Spleen Antibodies  >20 publications with LITAF and Spleen
 Muscle Antibodies  >18 publications with LITAF and Muscle
 Liver Antibodies  >17 publications with LITAF and Liver
 Heart Antibodies  >12 publications with LITAF and Heart
 Kidney Antibodies  >7 publications with LITAF and Kidney
 Bone Antibodies  >6 publications with LITAF and Bone
 Brain Antibodies  >6 publications with LITAF and Brain
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